Camptothecin

Name: Camptothecin
Brand: Tocris Bioscience
SKU: 1100

Catalog # 1100

Citations (6)

COA / SDS

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Key Product Details

Description:	DNA topoisomerase inhibitor
Chemical Name:	(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	348.36

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Biological Activity

Camptothecin is a cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.

Technical Data

M. Wt	348.36
Formula	C₂₀H₁₆N₂O₄
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	7689-03-4
PubChem ID	24360
InChi Key	VSJKWCGYPAHWDS-FQEVSTJZSA-N
Smiles	O=C4C5=C([C@](CC)(O)C(OC5)=O)C=C3C2=NC1=CC=CC=C1C=C2CN34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		5

Preparing Stock Solutions

The following data is based on the product molecular weight 348.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	57.41 mL	287.06 mL	574.12 mL
0.25 mM	11.48 mL	57.41 mL	114.82 mL
0.5 mM	5.74 mL	28.71 mL	57.41 mL
2.5 mM	1.15 mL	5.74 mL	11.48 mL

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References

References are publications that support the biological activity of the product.

Pantazis Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 1993 PMID: 8449612
Liu DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 1989 PMID: 2549853
Hsiang Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 1985 PMID: 2997227

Citations for Camptothecin (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Camptothecin include:

Herz et al. (2017) Evaluation of an Aqueous Extract from Horseradish Root (Armoracia rusticana Radix) against Lipopolysaccharide-Induced Cellular Inflammation Reaction. Evid Based Complement Alternat Med. 2017:1950692
PMID: 28182113
Neveu et al. (2016) CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia. Haematologica. 2016;
PMID: 27540136
Hellinger et al. (2013) Immunosuppressive activity of an aqueous Viola tricolor herbal extract. J Ethnopharmacol. 151:299
PMID: 24216163
Gründemann et al. (2013) Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. PLoS One. 8:e68016
PMID: 23840803
Lamy et al. (2013) Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status. PLoS One. 8:e70846
PMID: 23936472
Ma et al. (2005) Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. Sci Rep. 280:16208
PMID: 15687501

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