C 021 dihydrochloride

Name: C 021 dihydrochloride
Brand: Tocris Bioscience
SKU: 3581
Rating: 1 (1 reviews)

Catalog # 3581 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (7)

COA / SDS

Potent CCR4 antagonist

Key Product Details

Description:	Potent CCR4 antagonist
Chemical Name:	2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	540.57

View Full Technical Details for C 021 dihydrochloride

Technical Data
Citations (7) / Reviews (1)

Biological Activity for C 021 dihydrochloride

C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC₅₀ values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).

Compound Libraries for C 021 dihydrochloride

C 021 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for C 021 dihydrochloride

M. Wt	540.57
Formula	C₂₇H₄₁N₅O₂.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1784252-84-1
PubChem ID	56972238
InChi Key	GKJKNYQUFAPLOQ-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=C(N=C(N4CCC(N5CCCCC5)CC4)N=C2NC3CCCCCC3)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C 021 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.96	50
	DMSO	53.93	100

Preparing Stock Solutions for C 021 dihydrochloride

The following data is based on the product molecular weight 540.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.25 mL	18.50 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Reconstitution Calculator

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References for C 021 dihydrochloride

References are publications that support the biological activity of the product.

Yokoyama Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 2009 PMID: 19081254

Citations for C 021 dihydrochloride (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for C 021 dihydrochloride include:

Lei et al. (2021) Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice. J Neuroinflammation. 18:62
PMID: 33648537
Lei et al. (2020) Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice. Neurotherapeutics. 17:1940-1953
PMID: 32783091
Palchevskiy et al. (2019) CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. JCI Insight. 5
PMID: 31085832
Rasheed et al. (2018) CCL17/TARC and CCR4 expression in Merkel cell carcinoma. Oncotarget. 9:31432
PMID: 30140381
He et al. (2018) Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 49:1175
PMID: 30527911
Kwon et al. (2015) CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury. J Neurosci. 35:15934
PMID: 26631474
McMillin et al. (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 11:121
PMID: 25012628

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Customer Reviews for C 021 dihydrochloride (1)

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Unfortunately I found no effect.

Name: Anonymous

Species: Human

I used it both in vivo and in vitro. In vitro, I was unable to find any impact in chemotaxis towards CCL17

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