BTZO 1

Name: BTZO 1
Brand: Tocris Bioscience
SKU: 4204

Tocris Bioscience, part of Bio-Techne | Catalog # 4204

Citations (1)

COA / SDS

MIF binder

Key Product Details

Description:	MIF binder
Chemical Name:	2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	240.28

View Full Technical Details for BTZO 1

Technical Data
Citations

Biological Activity for BTZO 1

BTZO 1 binds macrophage migration inhibitory factor (MIF; K_d = 68.6 nM) and activates antioxidant response element (ARE)-mediated gene expression. BTZO 1 suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro and is cardioprotective.

Compound Libraries for BTZO 1

BTZO 1 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of BTZO 1 is reviewed on chemicalprobes.org and the SGC website.

Technical Data for BTZO 1

M. Wt	240.28
Formula	C₁₃H₈N₂OS
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	99420-15-2
PubChem ID	9837640
InChi Key	GBAKVEWPYUIGHN-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC=C1SC(C3=NC=CC=C3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BTZO 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.81	20 with gentle warming

Preparing Stock Solutions for BTZO 1

The following data is based on the product molecular weight 240.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	20.81 mL	104.05 mL	208.09 mL
1 mM	4.16 mL	20.81 mL	41.62 mL
2 mM	2.08 mL	10.40 mL	20.81 mL
10 mM	0.42 mL	2.08 mL	4.16 mL

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References for BTZO 1

References are publications that support the biological activity of the product.

Kimura BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 2010 PMID: 21168764