Product Description
BTZO 1 binds macrophage migration inhibitory factor (MIF; Kd = 68.6 nM) and activates antioxidant response element (ARE)-mediated gene expression. BTZO 1 suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro and is cardioprotective.External Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of BTZO 1 is reviewed on chemicalprobes.org and the SGC website.Product Specifications
Molecular Weight
240.28
Formula
C13H8N2OS
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
CAS Number
99420-15-2
PubChem ID
9837640
InChI Key
GBAKVEWPYUIGHN-UHFFFAOYSA-N
SMILES
O=C2C1=CC=CC=C1SC(C3=NC=CC=C3)=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.81 | 20 with gentle warming |
Preparing Stock Solutions
for BTZO 1
The following data is based on the product molecular weight 240.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 20.81 mL | 104.05 mL | 208.09 mL |
| 1 mM | 4.16 mL | 20.81 mL | 41.62 mL |
| 2 mM | 2.08 mL | 10.40 mL | 20.81 mL |
| 10 mM | 0.42 mL | 2.08 mL | 4.16 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kimura BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 2010 PMID: 21168764
Product Specific Notices for BTZO 1
For research use only
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