BSJ-4-116
Tocris Bioscience, part of Bio-Techne | Catalog # 7528
Selective CDK12 PROTAC® Degrader
Product Description
BSJ-4-116 is a selective CDK12 PROTAC® Degrader. BSJ-4-116 selectively degrades CDK12 over a panel of other kinases and exhibits no degradation of CDK13 or cyclin K. The compound inhibits growth of T-ALL cells and sensitizes them to PARP inhibitor Olaparib (Cat. No. 7579).PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
837.39
Formula
C40H49ClN8O8S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[7-[(3R)-3-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
CAS Number
2519823-34-6
PubChem ID
155235839
InChI Key
YJOJMGTVKMABKQ-FIQOPJFZSA-N
SMILES
CC(S(=O)(C1=C(C=CC=C1)NC2=NC(N[C@@H]3CCCN(C3)CCCCCCCNC(COC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)=NC=C2Cl)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 83.74 | 100 |
Preparing Stock Solutions
for BSJ-4-116
The following data is based on the product molecular weight 837.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.19 mL | 5.97 mL | 11.94 mL |
| 5 mM | 0.24 mL | 1.19 mL | 2.39 mL |
| 10 mM | 0.12 mL | 0.60 mL | 1.19 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jiang Discovery and resistance mechanism of a selective CDK12 degrader. Nat.Chem.Biol. 2021 PMID: 33753926
Product Specific Notices for BSJ-4-116
For research use only
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