BSJ-03-204
Tocris Bioscience, part of Bio-Techne | Catalog # 6938
Selective Cdk4/6 Degrader (PROTAC®
Product Description
BSJ-03-204 is a selective Cdk4/6 Degrader (PROTAC®). Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.CDK4 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF5254 and NBP1-31308.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
832.92
Formula
C43H48N10O8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
CAS Number
2349356-09-6
SMILES
CC1=C(C(N(C2=C1C=NC(NC3=CC=C(C=N3)N4CCN(CC4)CCCCNC(COC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)=O)=N2)C8CCCC8)=O)C(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.66 | 20 |
Preparing Stock Solutions
for BSJ-03-204
The following data is based on the product molecular weight 832.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 6.00 mL | 30.01 mL | 60.03 mL |
| 1 mM | 1.20 mL | 6.00 mL | 12.01 mL |
| 2 mM | 0.60 mL | 3.00 mL | 6.00 mL |
| 10 mM | 0.12 mL | 0.60 mL | 1.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jiang Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 2019 PMID: 30802347
Product Specific Notices for BSJ-03-204
For research use only
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