BSJ-03-123
Tocris Bioscience, part of Bio-Techne | Catalog # 6921
Selective Cdk6 Degrader (PROTAC®)
Product Description
BSJ-03-123 is a selective Cdk6 Degrader (PROTAC®) (DC50 in sub 10 μM range). Displays no degradation of closely related Cdk4.Negative control BSJ-Bump (Cat. No. 6922) and Cdk6 antibody validated for Western Blot also available: Catalog # NBP1-87262.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
937.02
Formula
C47H56N10O11
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
CAS Number
2361493-16-3
PubChem ID
137628658
InChI Key
LUHCYAOYQIFNRN-UHFFFAOYSA-N
SMILES
O=C1N(C2=NC(NC3=CC=C(C=N3)N4CCN(CCOCCOCCOCCNC(COC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)CC4)=NC=C2C(C)=C1C(C)=O)C8CCCC8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 93.7 | 100 |
Preparing Stock Solutions
for BSJ-03-123
The following data is based on the product molecular weight 937.02
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.07 mL | 5.34 mL | 10.67 mL |
| 5 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 10 mM | 0.11 mL | 0.53 mL | 1.07 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brand Homolog-selective degradation as a strategy to probe the function of CDK6 in AML. Cell Chem.Biol. 2019 PMID: 30595531
Product Specific Notices for BSJ-03-123
For research use only
Loading...
Loading...