Boc-MLF

Tocris Bioscience, part of Bio-Techne | Catalog # 3730

Citations (14)

COA / SDS

FPR1 antagonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

FPR1 antagonist

View all Formyl Peptide Receptor Antagonists »

Product Description

Boc-MLF is an antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC₅₀ of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.

Product Specifications

Molecular Weight

509.66

Formula

C₂₅H₃₉N₃O₆S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

67247-12-5

PubChem ID

14655143

InChI Key

GYBXWOPENJVQKE-UFYCRDLUSA-N

SMILES

O=C([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CCSC)=O)CC(C)C)N[C@H]([C@@](O)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in DMSO

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Stenfeldt Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 2007 PMID: 17687636
Karlsson Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol.
Boxio The immunostimulatory peptide WKYMVm-NH₂ activates bone marrow mouse neutrophils via multiple signal transduction pathways. Scand.J.Immunol. 2005 PMID: 16101820