BMS CCR2 22

Name: BMS CCR2 22
Brand: Tocris Bioscience
SKU: 3129

Tocris Bioscience, part of Bio-Techne | Catalog # 3129

Citations (22)

COA / SDS

High affinity, potent CCR2 antagonist

Key Product Details

Description:	High affinity, potent CCR2 antagonist
Chemical Name:	2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	593.66

View Full Technical Details for BMS CCR2 22

Technical Data
Citations

Biological Activity for BMS CCR2 22

BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist (IC₅₀ = 5.1 nM). Displays potent functional antagonism, IC₅₀ values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

Compound Libraries for BMS CCR2 22

BMS CCR2 22 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BMS CCR2 22

M. Wt	593.66
Formula	C₂₈H₃₄F₃N₅O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	445479-97-0
PubChem ID	24801690
InChi Key	IBPXYDUJQWENPM-XZOQPEGZSA-N
Smiles	O=C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=C(NC(NC(C)C)=O)C=CC(C(F)(F)F)=C3)=O)=O)C1=CC=C(SC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS CCR2 22

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	59.37	100
	ethanol	5.94	10

Preparing Stock Solutions for BMS CCR2 22

The following data is based on the product molecular weight 593.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.68 mL	8.42 mL	16.84 mL
5 mM	0.34 mL	1.68 mL	3.37 mL
10 mM	0.17 mL	0.84 mL	1.68 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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Reconstitution Calculator

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References for BMS CCR2 22

References are publications that support the biological activity of the product.

You CCR2 receptor ligands inhibit Ca_v3.2 T-type calcium channels. Mol.Pharmacol. 2010 PMID: 19864434
Cherney Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 2008 PMID: 18232650