BMS CCR2 22

Name: BMS CCR2 22
Brand: Tocris Bioscience
SKU: 3129

Tocris Bioscience a Bio-Techne Brand

Catalog # 3129

Citations (4)

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Key Product Details

Description:	High affinity, potent CCR2 antagonist
Chemical Name:	2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	593.66

View Full Technical Details for BMS CCR2 22

Biological Activity for BMS CCR2 22

BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist (IC₅₀ = 5.1 nM). Displays potent functional antagonism, IC₅₀ values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

Compound Libraries for BMS CCR2 22

BMS CCR2 22 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BMS CCR2 22

M. Wt	593.66
Formula	C₂₈H₃₄F₃N₅O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	445479-97-0
PubChem ID	24801690
InChi Key	IBPXYDUJQWENPM-XZOQPEGZSA-N
Smiles	O=C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=C(NC(NC(C)C)=O)C=CC(C(F)(F)F)=C3)=O)=O)C1=CC=C(SC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS CCR2 22

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	59.37	100
	ethanol	5.94	10

Preparing Stock Solutions for BMS CCR2 22

The following data is based on the product molecular weight 593.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.68 mL	8.42 mL	16.84 mL
5 mM	0.34 mL	1.68 mL	3.37 mL
10 mM	0.17 mL	0.84 mL	1.68 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for BMS CCR2 22

References are publications that support the biological activity of the product.

You CCR2 receptor ligands inhibit Ca_v3.2 T-type calcium channels. Mol.Pharmacol. 2010 PMID: 19864434
Cherney Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 2008 PMID: 18232650

Citations for BMS CCR2 22 (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for BMS CCR2 22 include:

Wang et al. (2022) Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer. Cell Death Dis. 13:748
PMID: 36038549
Wang et al. (2018) Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction. Int J Nanomedicine. 13:6441
PMID: 30410330
Barzilai et al. (2016) M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration. J Leukoc Biol. 99:1045
PMID: 26701136
Volpe et al. (2012) CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One. 7:e37208
PMID: 22615942

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Product Documents for BMS CCR2 22

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Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.