BMS 753

Name: BMS 753
Brand: Tocris Bioscience
SKU: 3505

Catalog # 3505 | Tocris Bioscience a Bio-Techne Brand

Citations (3)

COA / SDS

RARα-selective agonist

Key Product Details

Description:	RARα-selective agonist
Chemical Name:	4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	351.4

View Full Technical Details for BMS 753

Technical Data
Citations (3) / Reviews

Biological Activity for BMS 753

BMS 753 is a RARα-selective agonist (K_i = 2 nM).

Compound Libraries for BMS 753

BMS 753 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 753

M. Wt	351.4
Formula	C₂₁H₂₁NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	215307-86-1
PubChem ID	9884820
InChi Key	KFBPBWUZXBYJDG-UHFFFAOYSA-N
Smiles	O=C1C(C)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 753

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.14	100
	ethanol	35.14	100

Preparing Stock Solutions for BMS 753

The following data is based on the product molecular weight 351.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.46 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Molarity Calculator

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Reconstitution Calculator

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References for BMS 753

References are publications that support the biological activity of the product.

Gehin Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 1999 PMID: 10421757
Dilworth Ligand-dependent activation of transcription in vitro by retinoid acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo. Proc.Natl.Acad.Sci.USA 1999 PMID: 10051583
Taneja Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 1996 PMID: 8650243

Citations for BMS 753 (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for BMS 753 include:

Vincent M et al. (2022) Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models. J Tissue Eng. 13:20417314221127908
PMID: 36277058
Yuan et al. (2019) Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology. Immunity. 50:106-120.e10
PMID: 30650370
Raverdeau et al. (2012) Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis. Proc Natl Acad Sci U S A. 109:16582
PMID: 23012458

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