BI 78D3
Tocris Bioscience, part of Bio-Techne | Catalog # 3314
Selective, competitive JNK inhibitor
Key Product Details
Description
Selective, competitive JNK inhibitor
Product Description
BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.Product Specifications
Molecular Weight
379.37
Formula
C13H9N5O5S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one
CAS Number
883065-90-5
PubChem ID
2747117
InChI Key
QFRLDZGQEZCCJZ-UHFFFAOYSA-N
SMILES
O=C1NN=C(SC3=NC=C([N+]([O-])=O)S3)N1C2=CC=C4C(OCCO4)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.94 | 100 | |
| Ethanol | 1.9 | 5 |
Preparing Stock Solutions
for BI 78D3
The following data is based on the product molecular weight 379.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.64 mL | 13.18 mL | 26.36 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.27 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.64 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Flight Getting rid of JNK. Nat.Rev.Drug Disc.
- Haas and Writer Block JNK at the dock. SCiBX
- Stebbins Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc.Natl.Acad.Sci.USA 2008 PMID: 1892277
Product Specific Notices for BI 78D3
For research use only
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