BI-6901
Tocris Bioscience, part of Bio-Techne | Catalog # 6141
Potent and selective CCR10 antagonist
Key Product Details
Description
Potent and selective CCR10 antagonist
Product Description
BI-6901 is a potent and selective CCR10 antagonist (IC50 = 1 - 25 nM). BI-6901 inhibits CCL27-dependent chemotaxis of Ba/F3 cells (IC50 = 1 nM) and reduces inflammation in a DNFB-stimulated animal model of contact hypersensitivity.Product Specifications
Molecular Weight
453.56
Formula
C23H27N5O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1R)-3-(2-Cyano-1H-pyrrol-1-yl)-1-[(4-methyl-1-piperidinyl)carbonyl]propyl]-1H-indole-4-sulfonamide
CAS Number
2040401-92-9
PubChem ID
131801164
InChI Key
BRJXJOWXAFLRTE-OAQYLSRUSA-N
SMILES
CC1CCN(C([C@H](NS(=O)(C2=C3C=CNC3=CC=C2)=O)CCN4C=CC=C4C#N)=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.36 | 100 | |
| Ethanol | 45.36 | 100 |
Preparing Stock Solutions
for BI-6901
The following data is based on the product molecular weight 453.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.20 mL | 11.02 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.41 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Abeywardane N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg.Med.Chem.Lett. 2016 PMID: 27692854
Product Specific Notices for BI-6901
For research use only
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