Benzamil

Tocris Bioscience, part of Bio-Techne | Catalog # 3380

NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative
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Key Product Details

Description

NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative

View all Na+/Ca2+ Exchanger Inhibitors »

Product Description

Benzamil is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).

Product Specifications

Molecular Weight

356.21

Formula

C13H14ClN7O.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride

CAS Number

161804-20-2

PubChem ID

5702295

InChI Key

ZNWMRWWNJBXNKJ-UHFFFAOYSA-N

SMILES

NC1=C(Cl)N=C(C(NC(NCC2=CC=CC=C2)=N)=O)C(N)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.56 10
DMSO 35.62 100

Preparing Stock Solutions for Benzamil

The following data is based on the product molecular weight 356.21

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.04 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.40 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Benzamil

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Benzamil

For research use only

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