BD 1047 dihydrobromide
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | σ1 selective antagonist |
Chemical Name: | N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 437.04 |
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Citations for BD 1047 dihydrobromide (23)
Citations are publications that use Bio-Techne products. Selected citations for BD 1047 dihydrobromide include:
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Brailoiu et al.
(2019)
Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors.
Cell Rep.
26:330
PMID: 30625315 -
Sánchez-Blázquez et al.
(2018)
The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.
Mol Neurobiol.
55:4940
PMID: 28779350 -
Sánchez-Blázquez et al.
(2018)
Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
Int J Neuropsychopharmacol.
21:938
PMID: 29860313 -
Rodríguez-Muñoz et al.
(2015)
The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
Int J Neuropsychopharmacol.
6:35458
PMID: 26461475 -
Nguyen et al.
(2014)
Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
PLoS One.
9:e89985
PMID: 24587167 -
Gear et al.
(2014)
NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.
Neuroscience.
257:139
PMID: 24188792 -
Pan et al.
(2014)
σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
Exp Ther Med.
350:290
PMID: 24891452 -
Su et al.
(2014)
Effects of BD1047, aσ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells.
Oncotarget.
7:435
PMID: 24396420 -
Sánchez-Blázquez et al.
(2014)
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Korean J Physiol Pharmacol.
17:1943
PMID: 24485144 -
Pabba et al.
(2014)
NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
J Neurosci.
34:11325
PMID: 25143613 -
Moon et al.
(2014)
σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.
Br J Pharmacol.
171:5881
PMID: 25158784 -
Lesch et al.
(2014)
Activation and inhibition of transient receptor potential TRPM3-induced gene transcription.
Br J Pharmacol.
171:2645
PMID: 24895737 -
Kourrich et al.
(2013)
Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
Cell.
152:236
PMID: 23332758 -
Behensky et al.
(2013)
Afobazole activation of σ-1 receptors modulates neuronal responses to amyloid-β25-35.
J Pharmacol Exp Ther.
347:468
PMID: 24006338 -
Amer et al.
(2013)
Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands.
Br J Pharmacol.
168:1445
PMID: 23121507 -
Hiranita et al.
(2011)
Decreases in cocaine self-administration with dual inhibition of the DA transporter and σ receptors.
J Pharmacol Exp Ther.
339:662
PMID: 21859929 -
Roh et al.
(2011)
Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.
Br J Pharmacol.
163:1707
PMID: 21391983 -
Son and Kwon
(2010)
σ-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats.
J Neurophysiol.
14:359
PMID: 21311675 -
Yoon et al.
(2009)
Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.
Br J Pharmacol.
157:666
PMID: 19422393 -
Kwon et al.
(2009)
The Antinociceptive Effect of σ-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.
Br J Ophthalmol.
13:425
PMID: 20054487 -
Cantarella et al.
(2007)
Protective effects of the σ agonist Pre-084 in the rat retina.
Korean J Physiol Pharmacol.
91:1382
PMID: 17522150 -
Shin et al.
(2005)
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
Br J Pharmacol.
144:908
PMID: 15723099 -
Brown et al.
(2004)
Antitussive activity of sigma-1 receptor agonists in the guinea-pig.
Br J Pharmacol.
141:233
PMID: 14691051
There are no citations that match your criteria.
Customer Reviews for BD 1047 dihydrobromide (1)
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Species: MouseAssay Type: In VitroCell Line/Tissue: 661WMTT (cell viability assay) of 661W cultured cells. Cells were pretreated with sigma-1 receptor antagonist BD 1047. Results show that 100uM concentration of BD1047 significantly inhibited viability of this cell line.
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