BAY 58-2667 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6052
Potent soluble guanylyl cyclase (sGC) activator
Key Product Details
Description
Potent soluble guanylyl cyclase (sGC) activator
Alternative Names
Cinaciguat hydrochloride
Product Description
BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.Product Specifications
Molecular Weight
602.16
Formula
C36H39NO5.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
CAS Number
646995-35-9
PubChem ID
10031513
InChI Key
LLHMBJOVHATVSP-UHFFFAOYSA-N
SMILES
OC(CCCCN(CC1=CC=C(C(O)=O)C=C1)CCC2=C(C=CC=C2)OCC3=CC=C(C=C3)CCC4=CC=CC=C4)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 60.22 | 100 |
Preparing Stock Solutions
for BAY 58-2667 hydrochloride
The following data is based on the product molecular weight 602.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.66 mL | 8.30 mL | 16.61 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Stasch Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J.Clin.Invest. 2006 PMID: 16955146
- Roy Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br.J.Pharmacol. 2008 PMID: 18204474
- Stasch NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br.J.Pharmacol. 2002 PMID: 12086987
Product Specific Notices for BAY 58-2667 hydrochloride
For research use only
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