BAY 41-2272

Tocris Bioscience, part of Bio-Techne | Catalog # 4430

Soluble guanylyl cyclase (sGC) activator
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Key Product Details

Description

Soluble guanylyl cyclase (sGC) activator

View all Guanylyl Cyclase Activators »

Product Description

BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Product Specifications

Molecular Weight

360.39

Formula

C20H17FN6

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine

CAS Number

256376-24-6

PubChem ID

9798973

InChI Key

ATOAHNRJAXSBOR-UHFFFAOYSA-N

SMILES

FC(C=CC=C3)=C3CN2N=C(C4=NC=C(C5CC5)C(N)=N4)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.04 100

Preparing Stock Solutions for BAY 41-2272

The following data is based on the product molecular weight 360.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Product Documents for BAY 41-2272

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BAY 41-2272

For research use only

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