Bay 36-7620
Tocris Bioscience, part of Bio-Techne | Catalog # 2501
mGlu1 inverse agonist
Product Description
Bay 36-7620 is a selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.Licensing Information
Sold for research purposes under agreement from BayerProduct Specifications
Molecular Weight
278.35
Formula
C19H18O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
CAS Number
232605-26-4
PubChem ID
9903757
InChI Key
CVIRWLJKDBYYOG-MJGOQNOKSA-N
SMILES
C=C1C[C@@]2([H])[C@@](C(OC2)=O)(CC3=CC(C=CC=C4)=C4C=C3)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.84 | 100 | |
| Ethanol | 27.84 | 100 |
Preparing Stock Solutions
for Bay 36-7620
The following data is based on the product molecular weight 278.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.59 mL | 17.96 mL | 35.93 mL |
| 5 mM | 0.72 mL | 3.59 mL | 7.19 mL |
| 10 mM | 0.36 mL | 1.80 mL | 3.59 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- De Vry Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620. Eur.J.Pharmacol. 2001 PMID: 11675037
- Gil-Sanz Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice. Cereb.Cortex 2007 PMID: 18024992
- Carroll BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol.Pharmacol. 2001 PMID: 11306677
Product Specific Notices for Bay 36-7620
For research use only
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