AZD 9272
Tocris Bioscience, part of Bio-Techne | Catalog # 5613
Potent and selective mGlu5 antagonist; brain penetrant
Key Product Details
Description
Potent and selective mGlu5 antagonist; brain penetrant
Product Description
AZD 9272 is a potent and selective mGlu5 antagonist (IC50 values are 2.6 and 7.6 nM for rat and human receptors, respectively). Exhibits >3900-fold selectivity for mGlu5 over other mGlu receptors. Also selective over a panel of other targets. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.Product Specifications
Molecular Weight
284.22
Formula
C14H6F2N4O
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
CAS Number
327056-26-8
PubChem ID
9838729
InChI Key
RBSPCALDSNXWEP-UHFFFAOYSA-N
SMILES
FC1=CC=C(C2=NOC(C3=CC(F)=CC(C#N)=C3)=N2)N=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.21 | 50 |
Preparing Stock Solutions
for AZD 9272
The following data is based on the product molecular weight 284.22
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.04 mL | 35.18 mL | 70.37 mL |
| 2.5 mM | 1.41 mL | 7.04 mL | 14.07 mL |
| 5 mM | 0.70 mL | 3.52 mL | 7.04 mL |
| 25 mM | 0.14 mL | 0.70 mL | 1.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Raboisson Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg.Med.Chem.Lett. 2012 PMID: 23046966
- Swedberg and Raboisson AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 2014 PMID: 24876235
Product Specific Notices for AZD 9272
For research use only
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