AZ 5704
Tocris Bioscience, part of Bio-Techne | Catalog # 6330
Potent and selective ATM kinase inhibitor; orally bioavailable
Key Product Details
Description
Potent and selective ATM kinase inhibitor; orally bioavailable
Product Description
AZ 5704 is a potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan (CPT 11, Cat. No. 2688) in tumor bearing, immunocompromised mice. Orally bioavailable.Product Specifications
Molecular Weight
434.47
Formula
C23H23FN6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide
CAS Number
1941214-06-7
PubChem ID
130470684
InChI Key
XHNKFGYYGPLYPT-ZDUSSCGKSA-N
SMILES
COCC1=NC=C(C2=CC3=C(N=CC(C(N)=O)=C3N[C@H](C4=NN(C=C4)C)C)C=C2F)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.45 | 100 |
Preparing Stock Solutions
for AZ 5704
The following data is based on the product molecular weight 434.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.30 mL | 11.51 mL | 23.02 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.60 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Degorce Discovery of novel 3-quinoline carboxamides as potent, selective and orally bioavailable inhibitors of ataxia telangiectasia mutated (ATM) kinase. J.Med.Chem. 2016 PMID: 27259031
Product Specific Notices for AZ 5704
For research use only
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