AY 254

Name: AY 254
Brand: Tocris Bioscience
SKU: 7034

Tocris Bioscience a Bio-Techne Brand

Catalog # 7034

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Key Product Details

Description:	Potent PAR2 biased agonist; exhibits bias for ERK1/2 signaling
Purity:	≥95% (HPLC)
Molecular Weight:	631.77

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Biological Activity for AY 254

AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC₅₀ = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca²⁺ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.

Technical Data for AY 254

M. Wt	631.77
Formula	C₃₀H₄₉N₉O₆
Single Letter Sequence	XXAR (Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, Arg-4 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2093408-03-6
InChi Key	ZVDSAIOSGOWYAW-CKLTXHEASA-N
Smiles	O=C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AY 254

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Soluble to 2mg/ml in 0.1% acetic acid

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References for AY 254

References are publications that support the biological activity of the product.

Jiang Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 2017 PMID: 28169521

Citations for AY 254

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AY 254

Tocris Bioscience a Bio-Techne Brand

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