ASP 2535
Tocris Bioscience, part of Bio-Techne | Catalog # 5308
Potent and selective GlyT1 inhibitor
Key Product Details
Description
Potent and selective GlyT1 inhibitor
Product Description
ASP 2535 is a potent and selective GlyT1 inhibitor (IC50 = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.Product Specifications
Molecular Weight
382.42
Formula
C22H18N6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
CAS Number
374886-51-8
PubChem ID
9800113
InChI Key
FQGLDGKVKDPVLO-UHFFFAOYSA-N
SMILES
CC(C)C1=NN=C(C4=CN=C(C5=CC=CC=C5)C=C4)N1C3=CC=CC2=NON=C23
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.24 | 100 | |
| Ethanol | 38.24 | 100 |
Preparing Stock Solutions
for ASP 2535
The following data is based on the product molecular weight 382.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.07 mL | 26.15 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.23 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for ASP 2535
For research use only
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