AMG 837 hemicalcium salt

Name: AMG 837 hemicalcium salt
Brand: Tocris Bioscience
SKU: 6082

Tocris Bioscience, part of Bio-Techne | Catalog # 6082

COA / SDS

Potent FFA1 (GPR40) partial agonist

Key Product Details

Description:	Potent FFA1 (GPR40) partial agonist
Chemical Name:	(βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt
Purity:	≥98% (HPLC)
Molecular Weight:	457.47

View Full Technical Details for AMG 837 hemicalcium salt

Technical Data
Citations

Biological Activity for AMG 837 hemicalcium salt

AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC₅₀ values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid (Cat. No. 3687). Potentiates glucose-dependent stimulation of insulin in vivo. Antidiabetic.

Compound Libraries for AMG 837 hemicalcium salt

AMG 837 hemicalcium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AMG 837 hemicalcium salt

M. Wt	457.47
Formula	C₂₆H₂₀F₃O₃.½Ca
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1291087-14-3
PubChem ID	46854655
InChi Key	WCZAHGONZBHQSA-UHFFFAOYSA-L
Smiles	CC#C[C@H](C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)CC([O-])=O.CC#C[C@H](C4=CC=C(C=C4)OCC5=CC=CC(C6=CC=C(C(F)(F)F)C=C6)=C5)CC([O-])=O.[Ca+2]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG 837 hemicalcium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.75	100

Preparing Stock Solutions for AMG 837 hemicalcium salt

The following data is based on the product molecular weight 457.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.93 mL	21.86 mL
5 mM	0.44 mL	2.19 mL	4.37 mL
10 mM	0.22 mL	1.09 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for AMG 837 hemicalcium salt

References are publications that support the biological activity of the product.

Lin Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol.Pharmacol. 2012 PMID: 22859723
Lin AMG 837: a novel GPR40/FFA1 agonist that enhances Ins secretion and lowers glucose levels in rodents. PLoS One 2011 PMID: 22087278
Houze AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg.Med.Chem.Lett. 2012 PMID: 22217876