Docosahexaenoic acid is a endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.

Product Specifications

Molecular Weight

328.49

Formula

C₂₂H₃₂O₂

Storage

Store at -20°C

Purity

≥98%

Chemical Name

(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid

CAS Number

6217-54-5

PubChem ID

445580

InChI Key

MBMBGCFOFBJSGT-KUBAVDMBSA-N

SMILES

CC\C=C/C\C=C/C\C=C/C/C=C\C/C=C\C/C=C\CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.85	100
	Ethanol	32.85	100

Preparing Stock Solutions for Docosahexaenoic acid

The following data is based on the product molecular weight 328.49

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.22 mL	30.44 mL
5 mM	0.61 mL	3.04 mL	6.09 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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Background References

References are publications that support the biological activity of the product.

Zapata-Gonzalez Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids. J.Leukoc.Biol. 2008 PMID: 18632990
Hossain Mechanism of docosahexaenoic acid-induced inhibition of in vitro Aβ_1-42 fibrillation and Aβ_1-42-induced toxicity in SH-S5Y5 cells. J.Neurochem. 2009 PMID: 19686246
Mata de Urqunia Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 2000 PMID: 11118147

Docosahexaenoic acid

Tocris Bioscience, part of Bio-Techne | Catalog # 3687

Key Product Details

Description

Alternative Names

View all Retinoid X Receptor Agonists »

Product Description