AMG 21629
Tocris Bioscience, part of Bio-Techne | Catalog # 4330
Potent and selective TRPV1 antagonist
Product Description
AMG 21629 is a potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors (IC50 values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca2+ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.Product Specifications
Molecular Weight
472.42
Formula
C22H19F3N6O3
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone
CAS Number
939040-79-6
PubChem ID
24858024
InChI Key
TUMYQRZCVIQKOQ-UHFFFAOYSA-N
SMILES
NC(C(N4)=O)=NC(C4=CC=C3)=C3OC1=CC(C2=CC=C(C(F)(F)F)C=C2)=NC(NCCOC)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.62 | 50 |
Preparing Stock Solutions
for AMG 21629
The following data is based on the product molecular weight 472.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.23 mL | 21.17 mL | 42.34 mL |
| 2.5 mM | 0.85 mL | 4.23 mL | 8.47 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 25 mM | 0.08 mL | 0.42 mL | 0.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gavva The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J.Neurosci. 2007 PMID: 17392452
- Tamayo Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists. J.Med.Chem. 2008 PMID: 18386885
Product Specific Notices for AMG 21629
For research use only
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