AIDA

Tocris Bioscience a Bio-Techne Brand

Catalog # 0904

Citations (9)

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Key Product Details

Description:	Potent and selective group I mGlu antagonist
Alternative Names:	UPF 523
Chemical Name:	(RS)-1-Aminoindan-1,5-dicarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	221.21

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Biological Activity for AIDA

AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu_1a), having no effect on group II (mGlu₂) or group III (mGlu₄) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo.

Technical Data for AIDA

M. Wt	221.21
Formula	C₁₁H₁₁NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	168560-79-0
PubChem ID	2071
InChi Key	LSTPKMWNRWCNLS-UHFFFAOYSA-N
Smiles	NC2(C(O)=O)C1=CC=C(C(O)=O)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AIDA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1.1eq. NaOH	22.12	100

Preparing Stock Solutions for AIDA

The following data is based on the product molecular weight 221.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.52 mL	22.60 mL	45.21 mL
5 mM	0.90 mL	4.52 mL	9.04 mL
10 mM	0.45 mL	2.26 mL	4.52 mL
50 mM	0.09 mL	0.45 mL	0.90 mL

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References for AIDA

References are publications that support the biological activity of the product.

Moroni Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J.Pharmacol.Exp.Ther. 1997 PMID: 9152378
Nielsen Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur.J.Pharmacol. 1997 PMID: 9196260
Pellicciari 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J.Med.Chem. 1995 PMID: 7562903

Citations for AIDA (9)

Showing 1 - 9 of 9 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for AIDA include:

Saitoh et al. (2016) Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation Scientific Reports. 6:29856
PMID: 27432639
Mahler et al. (2014) Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Proc Natl Acad Sci U S A. 19:49
PMID: 23017017
Ady et al. (2014) Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors. J Neurosci. 15:103
PMID: 24357660
De-May and Ali (2013) Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex. J Neurophysiol. 109:216
PMID: 23054605
Cassé et al. (2012) Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci. 32:5186
PMID: 22496564
Wibrand et al. (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci. 31:636
PMID: 20384810
Shin et al. (2008) Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. EMBO Rep. 105:746
PMID: 18174329
Pan et al. (2004) Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats. BMC Neurosci. 5:50
PMID: 15579204
Yeckel et al. (1999) Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism. Nat Neurosci. 2:625
PMID: 10404192

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Showing 1 - 9 of 9 citations Showing All

Product Documents for AIDA

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.