AH 7614

Tocris Bioscience, part of Bio-Techne | Catalog # 5256

COA / SDS

Selective FFA4 (GPR120) antagonist

Key Product Details

Description:	Selective FFA4 (GPR120) antagonist
Chemical Name:	4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	351.42

View Full Technical Details for AH 7614

Technical Data
Citations

Biological Activity for AH 7614

AH 7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC₅₀ values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for AH 7614

M. Wt	351.42
Formula	C₂₀H₁₇NO₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	6326-06-3
PubChem ID	233085
InChi Key	OZCQEUZTOAAWDK-UHFFFAOYSA-N
Smiles	CC(C=C4)=CC=C4S(NC2C3=C(C=CC=C3)OC1=CC=CC=C12)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AH 7614

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.14	100

Preparing Stock Solutions for AH 7614

The following data is based on the product molecular weight 351.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.46 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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Reconstitution Calculator

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References for AH 7614

References are publications that support the biological activity of the product.

Sparks Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 2014 PMID: 24881566