GSK 137647

Name: GSK 137647
Brand: Tocris Bioscience
SKU: 5257

Tocris Bioscience, part of Bio-Techne | Catalog # 5257

Citations (10)

COA / SDS

Potent and selective FFA4 (GPR120) agonist

Discontinued Product

5257 has been discontinued. View all Free Fatty Acid Receptor Agonists products.

Key Product Details

Description:	Potent and selective FFA4 (GPR120) agonist
Chemical Name:	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	305.39

View Full Technical Details for GSK 137647

Technical Data
Citations

Biological Activity for GSK 137647

GSK 137647 is a potent and selective FFA4 (GPR120) agonist (pEC₅₀ values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for GSK 137647

GSK 137647 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 137647

M. Wt	305.39
Formula	C₁₆H₁₉NO₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	349085-82-1
PubChem ID	743974
InChi Key	FQUAFMNPXPXOJE-UHFFFAOYSA-N
Smiles	CC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GSK 137647

References are publications that support the biological activity of the product.

Martin Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. J.Lipid Res. 2012 PMID: 22904345
Sparks Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 2014 PMID: 24881566