GSK 137647

Tocris Bioscience, part of Bio-Techne | Catalog # 5257

Potent and selective FFA4 (GPR120) agonist
Discontinued Product
5257 has been discontinued. View all Free Fatty Acid Receptor Agonists products.

Key Product Details

Description

Potent and selective FFA4 (GPR120) agonist

View all Free Fatty Acid Receptor Agonists »

Product Description

GSK 137647 is a potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications

Molecular Weight

305.39

Formula

C16H19NO3S

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide

CAS Number

349085-82-1

PubChem ID

743974

InChI Key

FQUAFMNPXPXOJE-UHFFFAOYSA-N

SMILES

CC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.54 100
Ethanol 15.27 50

Preparing Stock Solutions for GSK 137647

The following data is based on the product molecular weight 305.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.37 mL 32.75 mL
5 mM 0.65 mL 3.27 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for GSK 137647

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 137647

For research use only

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