Acetazolamide

Name: Acetazolamide
Brand: Tocris Bioscience
SKU: 6742

Tocris Bioscience a Bio-Techne Brand

Catalog # 6742

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Key Product Details

Description:	Carbonic anhydrase inhibitor
Chemical Name:	N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
Purity:	≥99% (HPLC)
Molecular Weight:	222.25

View Full Technical Details for Acetazolamide

Biological Activity for Acetazolamide

Acetazolamide is a carbonic anhydrase inhibitor. Modulates epileptiform synchronization in rat brain slices. Increases speed of synaptic vesicle recycling and changes synaptic performance in ex vivo murine neuromuscular junction. Lowers intracranial pressure in healthy rats. Also potentiates the antitumor effects of the HDAC inhibitor MS 275 (Cat. No. 6208).

Compound Libraries for Acetazolamide

Acetazolamide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Acetazolamide

M. Wt	222.25
Formula	C₄H₆N₄O₃S₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	59-66-5
PubChem ID	1986
InChi Key	BZKPWHYZMXOIDC-UHFFFAOYSA-N
Smiles	CC(NC1=NN=C(S(N)(=O)=O)S1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Acetazolamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.23	100

Preparing Stock Solutions for Acetazolamide

The following data is based on the product molecular weight 222.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.50 mL	22.50 mL	44.99 mL
5 mM	0.90 mL	4.50 mL	9.00 mL
10 mM	0.45 mL	2.25 mL	4.50 mL
50 mM	0.09 mL	0.45 mL	0.90 mL

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References for Acetazolamide

References are publications that support the biological activity of the product.

Bayat Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 PMID: 28235409
Uldall Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats. Neurosci.Lett. 2017 PMID: 28219789
Bertone Carbonic anhydrase inhibitor acetazol. shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction. Synapse. 2017 PMID: 28873252
Hamidi Carbonic anhydrase inhibition by acetazol. reduces in vitro epileptiform synchronization. Neuropharmacology. 2015 PMID: 25937211

Citations for Acetazolamide

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