AC 261066
Tocris Bioscience, part of Bio-Techne | Catalog # 4046
RARβ2 agonist
Product Description
AC 261066 is a potent RARβ2 agonist (pEC50 = 8.1). Selective over RARβ1, RARα and RARγ (pEC50 values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).Product Specifications
Molecular Weight
353.41
Formula
C17H20FNO4S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid
CAS Number
870773-76-5
PubChem ID
11530459
InChI Key
HSAOETBFVAWNRP-UHFFFAOYSA-N
SMILES
CC1=C(OCCOCCCC)N=C(C2=CC=C(C(O)=O)C(F)=C2)S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.34 | 100 | |
| Ethanol | 35.34 | 100 |
Preparing Stock Solutions
for AC 261066
The following data is based on the product molecular weight 353.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.83 mL | 14.15 mL | 28.30 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.83 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lund Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands. J.Med.Chem. 2009 PMID: 19239230
- Lund Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 2005 PMID: 16302793
Product Specific Notices for AC 261066
For research use only
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