AC 261066

Name: AC 261066
Brand: Tocris Bioscience
SKU: 4046

Tocris Bioscience, part of Bio-Techne | Catalog # 4046

Citations (10)

COA / SDS

RARβ2 agonist

Key Product Details

Description:	RARβ2 agonist
Chemical Name:	4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	353.41

View Full Technical Details for AC 261066

Technical Data
Citations

Biological Activity for AC 261066

AC 261066 is a potent RARβ2 agonist (pEC₅₀ = 8.1). Selective over RARβ1, RARα and RARγ (pEC₅₀ values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).

Compound Libraries for AC 261066

AC 261066 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 261066

M. Wt	353.41
Formula	C₁₇H₂₀FNO₄S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	870773-76-5
PubChem ID	11530459
InChi Key	HSAOETBFVAWNRP-UHFFFAOYSA-N
Smiles	CC1=C(OCCOCCCC)N=C(C2=CC=C(C(O)=O)C(F)=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 261066

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.34	100
	ethanol	35.34	100

Preparing Stock Solutions for AC 261066

The following data is based on the product molecular weight 353.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.30 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.41 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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Reconstitution Calculator

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References for AC 261066

References are publications that support the biological activity of the product.

Lund Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands. J.Med.Chem. 2009 PMID: 19239230
Lund Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 2005 PMID: 16302793