7-Chlorokynurenic acid

Name: 7-Chlorokynurenic acid
Brand: Tocris Bioscience
SKU: 0237
Price: 100 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0237

Citations (6)

COA / SDS

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Key Product Details

Description:	Potent competitive inhibitor of L-glutamate uptake
Chemical Name:	7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	223.62

View Full Technical Details for 7-Chlorokynurenic acid

Biological Activity for 7-Chlorokynurenic acid

7-Chlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Sodium Salt also available.

Compound Libraries for 7-Chlorokynurenic acid

7-Chlorokynurenic acid is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 7-Chlorokynurenic acid

M. Wt	223.62
Formula	C₁₀H₆ClNO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	18000-24-3
PubChem ID	1884
InChi Key	UAWVRVFHMOSAPU-UHFFFAOYSA-N
Smiles	OC(=O)C1=CC(O)=C2C=CC(Cl)=CC2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 7-Chlorokynurenic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.36	100

Preparing Stock Solutions for 7-Chlorokynurenic acid

The following data is based on the product molecular weight 223.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.47 mL	22.36 mL	44.72 mL
5 mM	0.89 mL	4.47 mL	8.94 mL
10 mM	0.45 mL	2.24 mL	4.47 mL
50 mM	0.09 mL	0.45 mL	0.89 mL

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References for 7-Chlorokynurenic acid

References are publications that support the biological activity of the product.

Bartlett Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 1998 PMID: 9776380
Kretschmer Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 1995 PMID: 7498252
Kemp 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.U.S.A. 1988 PMID: 2842779
Donald Characterization of [³H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol.

Citations for 7-Chlorokynurenic acid (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for 7-Chlorokynurenic acid include:

Biase et al. (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. Proc Natl Acad Sci U S A. 31:12650
PMID: 21880926
Baltan et al. (2008) White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci. 28:1479
PMID: 18256269
Shin et al. (2006) Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab. 26:1018
PMID: 16340958
Vigot et al. (2006) Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 50:589
PMID: 16701209
Casado et al. (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Proc Natl Acad Sci U S A. 97:11593
PMID: 11016958
Tacconi et al. (1993) Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis. Br J Pharmacol. 108:577
PMID: 8096780

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Showing 1 - 6 of 6 citations Showing All

Product Documents for 7-Chlorokynurenic acid

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.