7-Chlorokynurenic acid sodium salt

Name: 7-Chlorokynurenic acid sodium salt
Brand: Tocris Bioscience
SKU: 3697
Rating: 5 (0 reviews)

Catalog # 3697 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)

Key Product Details

Description:	Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
Chemical Name:	7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	245.59

View Full Technical Details for 7-Chlorokynurenic acid sodium salt

Biological Activity for 7-Chlorokynurenic acid sodium salt

7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Technical Data for 7-Chlorokynurenic acid sodium salt

M. Wt	245.59
Formula	C₁₀H₅ClNNaO₃
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1263094-00-3
PubChem ID	52974249
InChi Key	IFZYIORLNGNLEI-UHFFFAOYSA-M
Smiles	[Na+].OC1=CC(=NC2=CC(Cl)=CC=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 7-Chlorokynurenic acid sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	24.56	100

Preparing Stock Solutions for 7-Chlorokynurenic acid sodium salt

The following data is based on the product molecular weight 245.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.07 mL	20.36 mL	40.72 mL
5 mM	0.81 mL	4.07 mL	8.14 mL
10 mM	0.41 mL	2.04 mL	4.07 mL
50 mM	0.08 mL	0.41 mL	0.81 mL

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References for 7-Chlorokynurenic acid sodium salt

References are publications that support the biological activity of the product.

Bartlett Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 1998 PMID: 9776380
Kretschmer Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 1995 PMID: 7498252
Kemp 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.USA
Donald Characterization of the [³H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol.

Citations for 7-Chlorokynurenic acid sodium salt (2)

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Citations are publications that use Bio-Techne products. Selected citations for 7-Chlorokynurenic acid sodium salt include:

Jun Kyu et al. (2021) Projection-dependent heterogeneity of cerebellar granule cell calcium responses. Mol Brain. 14:63
PMID: 33789707
Roberto et al. (2021) PSD-95 protects synapses from β-amyloid. Cell Rep. 35:109194
PMID: 34077732

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Customer Reviews for 7-Chlorokynurenic acid sodium salt (1)

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Successful block of ion flow through NMDA receptors

Name: Anonymous

Assay Type: In Vitro

Cell Line/Tissue: Organotypic Hippocampus Slices

We used this drug in bath application to block ion flow through NMDA receptors and observe dendritic spine structural plasticity int he absence of ion flow.

We incubate with this drug for at least 30 minutes before use. We are using cultured hippocampus slices.

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Product Documents for 7-Chlorokynurenic acid sodium salt

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.