7-Chlorokynurenic acid sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 3697
Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
Key Product Details
Description
Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
Product Description
7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.Product Specifications
Molecular Weight
245.59
Formula
C10H5ClNNaO3
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
CAS Number
1263094-00-3
PubChem ID
52974249
InChI Key
IFZYIORLNGNLEI-UHFFFAOYSA-M
SMILES
[Na+].OC1=CC(=NC2=CC(Cl)=CC=C12)C([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 24.56 | 100 |
Preparing Stock Solutions
for 7-Chlorokynurenic acid sodium salt
The following data is based on the product molecular weight 245.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.07 mL | 20.36 mL | 40.72 mL |
| 5 mM | 0.81 mL | 4.07 mL | 8.14 mL |
| 10 mM | 0.41 mL | 2.04 mL | 4.07 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Donald Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol.
- Bartlett Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 1998 PMID: 9776380
- Kemp 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.USA
- Kretschmer Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 1995 PMID: 7498252
Product Specific Notices for 7-Chlorokynurenic acid sodium salt
For research use only
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