666-15

Name: 666-15
Brand: Tocris Bioscience
SKU: 5661
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5661

Citations (54)

COA / SDS

Potent and selective CREB inhibitor

Key Product Details

Description:	Potent and selective CREB inhibitor
Chemical Name:	3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	620.52

View Full Technical Details for 666-15

Technical Data
Citations

Biological Activity for 666-15

666-15 is a potent and selective CREB inhibitor (IC₅₀ = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model.

Compound Libraries for 666-15

666-15 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 666-15

M. Wt	620.52
Formula	C₃₃H₃₀ClN₃O₅.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1433286-70-4
PubChem ID	71566396
InChi Key	LELLCPHHYHLWBH-UHFFFAOYSA-N
Smiles	NCCCOC1=CC2=CC=CC=C2C=C1C(NCCOC3=C(C(NC4=CC=C(Cl)C=C4O)=O)C=C(C=CC=C5)C5=C3)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 666-15

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	62.05	100

Preparing Stock Solutions for 666-15

The following data is based on the product molecular weight 620.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.61 mL	8.06 mL	16.12 mL
5 mM	0.32 mL	1.61 mL	3.22 mL
10 mM	0.16 mL	0.81 mL	1.61 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for 666-15

References are publications that support the biological activity of the product.

Li Systemic inhibition of CREB is well-tolerated in vivo. Sci.Rep. 2016 PMID: 27694829
Xie Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activity J.Med.Chem. 2015 PMID: 26023867