5,7-Dichlorokynurenic acid sodium salt

Name: 5,7-Dichlorokynurenic acid sodium salt
Brand: Tocris Bioscience
SKU: 3698

Tocris Bioscience a Bio-Techne Brand

Catalog # 3698

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Key Product Details

Description:	Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid
Chemical Name:	5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	280.04

View Full Technical Details for 5,7-Dichlorokynurenic acid sodium salt

Biological Activity for 5,7-Dichlorokynurenic acid sodium salt

5,7-Dichlorokynurenic acid sodium salt is a sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (K_i = 79 nM vs. [³H]-glycine).

Technical Data for 5,7-Dichlorokynurenic acid sodium salt

M. Wt	280.04
Formula	C₁₀H₄Cl₂NNaO₃
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1184986-70-6
PubChem ID	44134672
InChi Key	VPRPMJHKWHCUFW-UHFFFAOYSA-M
Smiles	[Na+].OC1=CC(=NC2=CC(Cl)=CC(Cl)=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 5,7-Dichlorokynurenic acid sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	28	100

Preparing Stock Solutions for 5,7-Dichlorokynurenic acid sodium salt

The following data is based on the product molecular weight 280.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.57 mL	17.85 mL	35.71 mL
5 mM	0.71 mL	3.57 mL	7.14 mL
10 mM	0.36 mL	1.79 mL	3.57 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

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References for 5,7-Dichlorokynurenic acid sodium salt

References are publications that support the biological activity of the product.

Baron Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 1990 PMID: 2172769
Moore Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I

Citations for 5,7-Dichlorokynurenic acid sodium salt

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5,7-Dichlorokynurenic acid sodium salt

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Biological Activity for 5,7-Dichlorokynurenic acid sodium salt

Technical Data for 5,7-Dichlorokynurenic acid sodium salt

Solubility for 5,7-Dichlorokynurenic acid sodium salt

Preparing Stock Solutions for 5,7-Dichlorokynurenic acid sodium salt

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 5,7-Dichlorokynurenic acid sodium salt

Citations for 5,7-Dichlorokynurenic acid sodium salt

Product Documents for 5,7-Dichlorokynurenic acid sodium salt

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