5,7-Dichlorokynurenic acid
Tocris Bioscience, part of Bio-Techne | Catalog # 0286
Potent NMDA antagonist; acts at glycine site
Discontinued Product
0286 has been discontinued.
View all NMDA Receptor Antagonists products.
Key Product Details
Description
Potent NMDA antagonist; acts at glycine site
Product Description
5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).Sodium Salt also available.
Product Specifications
Molecular Weight
258.06
Formula
C10H5Cl2NO3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
CAS Number
131123-76-7
PubChem ID
1779
InChI Key
BGKFPRIGXAVYNX-UHFFFAOYSA-N
SMILES
OC(=O)C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 | ||
| 1eq. NaOH | 100 |
Preparing Stock Solutions
for 5,7-Dichlorokynurenic acid
The following data is based on the product molecular weight 258.06
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.88 mL | 19.38 mL | 38.75 mL |
| 5 mM | 0.78 mL | 3.88 mL | 7.75 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.88 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Moore Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I
- Baron Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 1990 PMID: 2172769
Product Specific Notices for 5,7-Dichlorokynurenic acid
For research use only
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