5,7-Dichlorokynurenic acid

Name: 5,7-Dichlorokynurenic acid
Brand: Tocris Bioscience
SKU: 0286

Catalog # 0286

Citations (4)

COA / SDS

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Key Product Details

Description:	Potent NMDA antagonist; acts at glycine site
Chemical Name:	5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	258.06

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Biological Activity

5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (K_i = 79 nM vs. [³H]-glycine).

Sodium Salt also available.

Compound Libraries

5,7-Dichlorokynurenic acid is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	258.06
Formula	C₁₀H₅Cl₂NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	131123-76-7
PubChem ID	1779
InChi Key	BGKFPRIGXAVYNX-UHFFFAOYSA-N
Smiles	OC(=O)C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	1eq. NaOH	100
	DMSO	100

Preparing Stock Solutions

The following data is based on the product molecular weight 258.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.88 mL	19.38 mL	38.75 mL
5 mM	0.78 mL	3.88 mL	7.75 mL
10 mM	0.39 mL	1.94 mL	3.88 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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References

References are publications that support the biological activity of the product.

Baron Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 1990 PMID: 2172769
Moore Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I

Citations for 5,7-Dichlorokynurenic acid (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for 5,7-Dichlorokynurenic acid include:

Adamsky et al. (2018) Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement. Cell. 174:59
PMID: 29804835
Astorga et al. (2015) An excitatory GABA loop operating in vivo. Front Cell Neurosci. 9:275
PMID: 26236197
Stevens et al. (2010) Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Cell Commun Signal. 21:239
PMID: 20101193
Kenny et al. (2009) The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem. 284:324
PMID: 18990687

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