3-Bromo-7-nitroindazole

Name: 3-Bromo-7-nitroindazole
Brand: Tocris Bioscience
SKU: 0735

Catalog # 0735

Citations (1)

COA / SDS

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Key Product Details

Description:	Selective nNOS inhibitor
Purity:	≥98% (HPLC)
Molecular Weight:	242.03

View Full Technical Details for 3-Bromo-7-nitroindazole

Biological Activity

3-Bromo-7-nitroindazole is a potent inhibitor of rat cerebellar nitric oxide synthase; more potent than 7-nitroindazole (Cat. No. 0602).

Technical Data

M. Wt	242.03
Formula	C₇H₄BrN₃O₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	74209-34-0
PubChem ID	1649
InChi Key	NFSTZPMYAZRZPC-UHFFFAOYSA-N
Smiles	[O-][N+](=O)C1=C2NN=C(Br)C2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.2	100
	ethanol	12.1	50

Preparing Stock Solutions

The following data is based on the product molecular weight 242.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.13 mL	20.66 mL	41.32 mL
5 mM	0.83 mL	4.13 mL	8.26 mL
10 mM	0.41 mL	2.07 mL	4.13 mL
50 mM	0.08 mL	0.41 mL	0.83 mL

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References

References are publications that support the biological activity of the product.

Bland-Ward and Moore 7-Nitroindazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 1995 PMID: 7544863
Bland-Ward Isoform selectivity of indazole-based nitric oxide synthase inhibitors. Br.J.Pharmacol.

Citations for 3-Bromo-7-nitroindazole (1)

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Citations are publications that use Bio-Techne products. Selected citations for 3-Bromo-7-nitroindazole include:

Dai et al. (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol. 301:H1248
PMID: 21856924

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