7-Nitroindazole

Name: 7-Nitroindazole
Brand: tocris
SKU: 0602
Rating: 5 (1 reviews)

Catalog # 0602

Citations (2)

(1)

Datasheet / COA / SDS

Order Information

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Key Product Details

Description:	Non-selective NOS inhibitor
Purity:	≥98% (HPLC)
Molecular Weight:	163.14

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Biological Activity

7-Nitroindazole is a reversible, competitive and non-selective NOS inhibitor.

Monosodium Salt also available.

Technical Data

M. Wt	163.14
Formula	C₇H₅N₃O₂
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	2942-42-9
PubChem ID	1893
InChi Key	PQCAUHUKTBHUSA-UHFFFAOYSA-N
Smiles	[O-][N+](=O)C1=C2NN=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO		100
	ethanol	3.26	20

Preparing Stock Solutions

The following data is based on the product molecular weight 163.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.13 mL	30.65 mL	61.30 mL
5 mM	1.23 mL	6.13 mL	12.26 mL
10 mM	0.61 mL	3.06 mL	6.13 mL
50 mM	0.12 mL	0.61 mL	1.23 mL

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References

References are publications that support the biological activity of the product.

Babbedge Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br.J.Pharmacol. 1993 PMID: 7693279
Moore 7-nitroindazole, an inhibitor of nitric oxide synthase, exhibits antinociceptive activity in the mouse without increasing blood pressure. Br.J.Pharmacol. 1993 PMID: 7680591
Moore Characterisation of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 1993 PMID: 7693278
Moore and Handy Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 1997 PMID: 9226999

Citations (2)

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Citations are publications that use Bio-Techne products. Selected citations for 7-Nitroindazole include:

Yuan et al. (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 8:ra37
PMID: 25900831
Makara et al. (2007) Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J Neurosci. 27:10211
PMID: 17881527

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Used for local infusions in the perturbation of NOS signalling

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

Local Infusions

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Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

7-Nitroindazole

Order Information

Key Product Details

Complete Your Research

Complete Your Experiment

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (2)

Customer Reviews (1)

Used for local infusions in the perturbation of NOS signalling

Product Datasheets

COA

Certificate of Analysis

SDS

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