2S,6S-Hydroxynorketamine hydrochloride

Name: 2 S ,6 S -Hydroxynorketamine hydrochloride
Brand: Tocris Bioscience
SKU: 6095

Catalog # 6095 | Tocris Bioscience a Bio-Techne Brand

Citations (4)

COA / SDS

Decreases D-serine (a NMDA co-agonist); antidepressant

Key Product Details

Description:	Decreases D-serine (a NMDA co-agonist); antidepressant
Chemical Name:	(2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	276.16

View Full Technical Details for 2S,6S-Hydroxynorketamine hydrochloride

Technical Data
Citations (4) / Reviews

Biological Activity

2S,6S-Hydroxynorketamine hydrochloride is a ketamine metabolite. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC₅₀ = 0.18 nM). Exerts antidepressant effects in mice.

2R,6R-Enantiomer and Racemate also available.

Licensing Information

Sold under license from the NIH, US patent 62/313,309

Technical Data

M. Wt	276.16
Formula	C₁₂H₁₄ClNO₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1430202-70-2
PubChem ID	124201855
InChi Key	ZQJVHBJDLMIKJK-JGAZGGJJSA-N
Smiles	ClC1=C([C@]2(N)C([C@@H](O)CCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	13.81	50
	DMSO	27.62	100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.11 mL	36.21 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References

References are publications that support the biological activity of the product.

Singh KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 2016 PMID: 27096720
Zanos NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 2016 PMID: 27144355

Citations for 2S,6S-Hydroxynorketamine hydrochloride (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for 2S,6S-Hydroxynorketamine hydrochloride include:

Eero et al. (2022) Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol. 12:755600
PMID: 35126106
Ye et al. (2019) KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology. 157
PMID: 31207251
Ago et al. (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol. 22:665
PMID: 31325908
Chou et al. (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology. 139:1
PMID: 29953886

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