2R,6R-Hydroxynorketamine hydrochloride

Name: 2 R ,6 R -Hydroxynorketamine hydrochloride
Brand: Tocris Bioscience
SKU: 6094

Catalog # 6094 | Tocris Bioscience a Bio-Techne Brand

Citations (10)

COA / SDS

Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects

Key Product Details

Description:	Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
Chemical Name:	(2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	276.16

View Full Technical Details for 2R,6R-Hydroxynorketamine hydrochloride

Technical Data
Citations (10) / Reviews

Biological Activity

2R,6R-Hydroxynorketamine hydrochloride is a ketamine metabolite. It enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices and decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC₅₀ = 0.68 nM). 2R,6R-Hydroxynorketamine upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. Exerts antidepressant effects in mice. Lacks ketamine-related side effects.

2S,6S-Enantiomer and Racemate also available.

Licensing Information

Sold under license from the NIH, US patent 62/313,309

Technical Data

M. Wt	276.16
Formula	C12H14ClNO2.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1430202-69-9
PubChem ID	121513910
InChi Key	ZQJVHBJDLMIKJK-MHDYBILJSA-N
Smiles	ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	13.81	50
	DMSO	27.62	100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.11 mL	36.21 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Lopez Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron 2022 PMID: 35649415
Singh KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 2016 PMID: 27096720
Zanos NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 2016 PMID: 27144355

Citations for 2R,6R-Hydroxynorketamine hydrochloride (10)

Showing 1 - 10 of 10 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for 2R,6R-Hydroxynorketamine hydrochloride include:

Plinio C et al. (2023) Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release tropomyosin-related kinase B from inhibitory control without reducing perineuronal nets enwrapping parvalbumin interneurons. Eur J Neurosci. 57:940-950
PMID: 36740723
Eero et al. (2023) TRKB interaction with PSD95 is associated with latency of fluoxetine and 2R,6R-hydroxynorketamine. Eur J Neurosci. 57:1215-1224
PMID: 36876503
Tomasz et al. (2023) Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nat Neurosci. 26:1032-1041
PMID: 37280397
Eero et al. (2022) Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol. 12:755600
PMID: 35126106
Jian-Hua et al. (2020) The Ventrolateral Periaqueductal Gray Contributes to Depressive-Like Behaviors in Recovery of Inflammatory Bowel Disease Rat Model. Front Neurosci. 14:254
PMID: 32265648
Xiangmin et al. (2020) Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia. Curr Biol. 30:3591-3603.e8
PMID: 32822611
Ye et al. (2019) KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology. 157
PMID: 31207251
Ago et al. (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol. 22:665
PMID: 31325908
Eero et al. (2019) Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2. J Biol Chem. 294:18150-18161
PMID: 31631060
Chou et al. (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology. 139:1
PMID: 29953886

There are no citations that match your criteria.