2R,6R-Hydroxynorketamine hydrochloride

Name: 2 R ,6 R -Hydroxynorketamine hydrochloride
Brand: Tocris Bioscience
SKU: 6094

Tocris Bioscience, part of Bio-Techne | Catalog # 6094

Citations (13)

COA / SDS

Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects

Key Product Details

Description:	Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
Chemical Name:	(2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	276.16

View Full Technical Details for 2R,6R-Hydroxynorketamine hydrochloride

Technical Data
Citations

Biological Activity

2R,6R-Hydroxynorketamine hydrochloride is a ketamine metabolite. It enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices and decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC₅₀ = 0.68 nM). 2R,6R-Hydroxynorketamine upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. Exerts antidepressant effects in mice. Lacks ketamine-related side effects.

2S,6S-Enantiomer and Racemate also available.

Licensing Information

Sold under license from the NIH, US patent 62/313,309

Technical Data

M. Wt	276.16
Formula	C12H14ClNO2.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1430202-69-9
PubChem ID	121513910
InChi Key	ZQJVHBJDLMIKJK-MHDYBILJSA-N
Smiles	ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	13.81	50
	DMSO	27.62	100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.11 mL	36.21 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References

References are publications that support the biological activity of the product.

Zanos NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 2016 PMID: 27144355
Lopez Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron 2022 PMID: 35649415
Singh KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 2016 PMID: 27096720