1A-116

Tocris Bioscience, part of Bio-Techne | Catalog # 6701

Rac1 inhibitor; blocks Rac1-P-Rex1 interaction
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Key Product Details

Description

Rac1 inhibitor; blocks Rac1-P-Rex1 interaction

View all Rho GTPase Inhibitors »

Product Description

1A-116 is a Rac1 inhibitor. Reduces intracellular Rac1-GTP levels and blocks Rac1-P-Rex1 interaction in vitro. Exhibits no effect on GTPase activity of closely related Cdc42. Displays antiproliferative, anti-invasive and pro-apoptotic activity in several cancer cell lines. Exhibits antimetastatic activity in vivo. Also restores antiproliferative effects of Tamoxifen (Cat. No. 6342) in resistant breast cancer cell.

Licensing Information

Sold under license from Romikin S.A.

Product Specifications

Molecular Weight

307.31

Formula

C16H16F3N3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]guanidine

CAS Number

1430208-73-3

PubChem ID

71543346

InChI Key

DVIJFJSZZNOTLP-UHFFFAOYSA-N

SMILES

CC1=CC(NC(NC2=C(C(F)(F)F)C=CC=C2)=N)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.73 100
Ethanol 30.73 100

Preparing Stock Solutions for 1A-116

The following data is based on the product molecular weight 307.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for 1A-116

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 1A-116

For research use only

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