17-AAG is an inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185^erbB-2 (IC₅₀ = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

Product Specifications

Molecular Weight

585.70

Formula

C₃₁H₄₃N₃O₈

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

17-Demethoxy-17-(2-propenylamino)geldanamycin

CAS Number

75747-14-7

PubChem ID

6440175

InChI Key

AYUNIORJHRXIBJ-HTLBVUBBSA-N

SMILES

O=C1C(NCC=C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.86	10

Preparing Stock Solutions for 17-AAG

The following data is based on the product molecular weight 585.70

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.07 mL	85.37 mL	170.74 mL
0.5 mM	3.41 mL	17.07 mL	34.15 mL
1 mM	1.71 mL	8.54 mL	17.07 mL
5 mM	0.34 mL	1.71 mL	3.41 mL

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Background References

References are publications that support the biological activity of the product.

Wang Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range. J.Neurochem. 2011 PMID: 21395580
Schnur Inhibition of the oncogene product p185^erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. J.Med.Chem. 1995 PMID: 7562911
Yang Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 2001 PMID: 11358819
Hostein Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 2001 PMID: 11358818

17-AAG

Tocris Bioscience, part of Bio-Techne | Catalog # 1515

Key Product Details

Description

Alternative Names

View all HSP90 Inhibitors »

Product Description