Geldanamycin

Tocris Bioscience, part of Bio-Techne | Catalog # 1368

Selective Hsp90 inhibitor
Discontinued Product
1368 has been discontinued. View all HSP90 Inhibitors products.

Key Product Details

Description

Selective Hsp90 inhibitor

View all HSP90 Inhibitors »

Product Description

Geldanamycin is a selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.

Product Specifications

Molecular Weight

560.64

Formula

C29H40N2O9

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate

CAS Number

30562-34-6

PubChem ID

13017912

InChI Key

QTQAWLPCGQOSGP-PHLMVCJGSA-N

SMILES

O=C1C(OC)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.61 10

Preparing Stock Solutions for Geldanamycin

The following data is based on the product molecular weight 560.64

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.18 mL 178.37 mL
0.5 mM 3.57 mL 17.84 mL 35.67 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

Calculators

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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Product Documents for Geldanamycin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Geldanamycin

For research use only

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