Z-DEVD-FMK Caspase-3 Inhibitor
Tocris Bioscience, part of Bio-Techne | Catalog # 8009
Caspase-3 Inhibitor
Product Description
Z-DEVD-FMK Caspase-3 Inhibitor is a cell-permeable, irreversible inhibitor of caspase-3/CPP32. It inhibits tumor cell apoptosis. In vivo, it has a neuroprotective effect in rat hippocampus following seizures. It also significantly reduces post-traumatic apoptosis, and improved neurological recovery, before and after induced traumatic brain injury in rat.Product Specifications
Molecular Weight
668.67
Formula
C30H41FN4O12
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
634911-78-7
InChI Key
GBJVAVGBSGRRKN-OXMHKTTFSA-N
SMILES
[H]N(C(OCC1=CC=CC=C1)=O)[C@H](C(N[C@H](C(N[C@H](C(NC(C(CF)=O)CC(OC)=O)=O)C(C)C)=O)CCC(OC)=O)=O)CC(OC)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in DMSO |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Yakovlev Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J.Neurosci. 1997 PMID: 9295387
- Henshall Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 2000 PMID: 10693954
- Kugawa Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 2000 PMID: 10963298
- Brocksted Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 1998 PMID: 9774422
Product Specific Notices for Z-DEVD-FMK Caspase-3 Inhibitor
For research use only
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