J 113863 is a potent chemokine receptor 1 (CCR1) antagonist (IC₅₀ values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC₅₀ values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice.

Isomer also available.

Product Specifications

Molecular Weight

655.44

Formula

C₃₀H₃₇Cl₂IN₂O₂

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide

CAS Number

202796-41-6

PubChem ID

6918496

InChI Key

FOAFBMYSXIGAOX-LQGGPMKRSA-N

SMILES

ClC1=CC=C(OC(C=CC(Cl)=C3)=C3C2C(N[C@@H]4CC[N@@+](C/C5=C/CCCCCC5)(CC)CC4)=O)C2=C1.ClC6=CC=C(OC(C=CC(Cl)=C8)=C8C7C(N[C@H]9CC[N@+](C/C%10=C/CCCCCC%10)(CC)CC9)=O)C7=C6.[I-].[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	65.54	100
	Ethanol	32.77	50

Preparing Stock Solutions for J 113863

The following data is based on the product molecular weight 655.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.53 mL	7.63 mL	15.26 mL
5 mM	0.31 mL	1.53 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.53 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

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Background References

References are publications that support the biological activity of the product.

Amat Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Br.J.Pharmacol. 2006 PMID: 17016504
Naya Design, synthesis, and discovery of a novel CCR1 antagonist. J.Med.Chem. 2001 PMID: 11311066

J 113863

Tocris Bioscience, part of Bio-Techne | Catalog # 2595

Key Product Details

Description

View all Chemokine Receptor Antagonists »

Product Description