5,7-Dichlorokynurenic acid sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 3698
Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid
Key Product Details
Description
Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid
Product Description
5,7-Dichlorokynurenic acid sodium salt is a sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).Product Specifications
Molecular Weight
280.04
Formula
C10H4Cl2NNaO3
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
CAS Number
1184986-70-6
PubChem ID
44134672
InChI Key
VPRPMJHKWHCUFW-UHFFFAOYSA-M
SMILES
[Na+].OC1=CC(=NC2=CC(Cl)=CC(Cl)=C12)C([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 28 | 100 |
Preparing Stock Solutions
for 5,7-Dichlorokynurenic acid sodium salt
The following data is based on the product molecular weight 280.04
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.57 mL | 17.85 mL | 35.71 mL |
| 5 mM | 0.71 mL | 3.57 mL | 7.14 mL |
| 10 mM | 0.36 mL | 1.79 mL | 3.57 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Moore Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I
- Baron Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 1990 PMID: 2172769
Product Specific Notices for 5,7-Dichlorokynurenic acid sodium salt
For research use only
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