Simple Plex Control for Human CTLA-4

Name: Simple Plex Control for Human CTLA-4
Brand: ProteinSimple
SKU: 898485

ProteinSimple, part of Bio-Techne | Catalog # 898485

Product Datasheet / COA

Control for use with Human and Non-Human Primate CTLA-4 Simple Plex Cartridge Kit

Key Product Details

Technical Data
Citations

Summary for Simple Plex Control for Human CTLA-4

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human and NHP CTLA-4 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.

Product Specifications for Simple Plex Control for Human CTLA-4

Species	Human, Non-human Primate
Applications	Control, Simple Plex Automated Immunoassay
Source	N/A

Preparation & Storage

Shipping Conditions

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Background: CTLA-4

Item	Value
Long Name	Cytotoxic T-lymphocyte-associated Molecule 4
Entrez Gene IDs	1493 (Human); 12477 (Mouse); 403696 (Canine); 102115124 (Cynomolgus Monkey)
Alternate Names	CD, CD152, CD152 antigen, CD152IDDM12, CD28, CELIAC3, CTLA-4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4, GRD4, GSE, ICOS, celiac disease 3, cytotoxic T-lymphocyte antigen 4, cytotoxic T-lymphocyte protein 4, cytotoxic T-lymphocyte-associated protein 4, cytotoxic T-lymphocyte-associated serine esterase-4, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Product Documents for Simple Plex Control for Human CTLA-4

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