Recombinant Mouse IL-6 Protein

Name: Recombinant Mouse IL-6 Protein
Brand: R&D Systems
SKU: 406-ML
Rating: 5 (13 reviews)

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 406-ML

Citations (323)

(13)

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Setting the standard in quality research reagents

Key Product Details

Source:	E. coli
Accession #:	P08505
Applications:	Bioactivity

View Full Technical Details for Recombinant Mouse IL-6 Protein

Product Specifications for Recombinant Mouse IL-6 Protein

Source	E. coli-derived mouse IL-6 protein Phe25-Thr211, with an N-terminal Met
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin level	<0.10 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Phe25
Predicted Molecular Mass	21.8 kDa
Activity	Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED₅₀ for this effect is 10.0-100 pg/mL.

Scientific Data Examples for Recombinant Mouse IL-6 Protein

	Recombinant Mouse IL-6 Protein Bioactivity Recombinant Mouse IL-6 (Catalog # 406‑ML) stimulates cell proliferation of the T1165.85.2.1 mouse plasmacytoma cell line. The ED₅₀ for this effect is 10.0-100 pg/mL.
	Recombinant Mouse IL-6 Protein SDS-PAGE 1 μg/lane of Recombinant Mouse IL-6 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 24 kDa.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

406-ML

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in Sodium Acetate and EDTA with Trehalose and with BSA as a carrier protein.
Reconstitution	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

406-ML/CF

Carrier Free

Formulation	Supplied as a 0.2 μm filtered solution in Sodium Acetate and EDTA.
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Do not freeze.Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, 2 to 8 °C as supplied.

Reconstitution Calculator

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Background: IL-6

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, 22 - 28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression (1 - 5). Mature mouse IL-6 is 187 amino acids (aa) in length and shares 39% and 85% aa sequence identity with human and rat IL-6, respectively (6 - 8). IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization (9). gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM (10). Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage (5). In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha (5). Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes (2, 5). Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor (5, 11). IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease (1 - 5). When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis (1, 2, 5). IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise (2). In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells (1, 12).

Item	Value
References	Mansell, A. and B.J. Jenkins (2013) Cytokine Growth Factor Rev. 24:249. Schuett, H. et al. (2009) Thromb. Haemost. 102:215. Erta, M. et al. (2012) Int. J. Biol. Sci. 8:1254. Garbers, C. et al. (2012) Cytokine Growth Factor Rev. 23:85. Mihara, M. et al. (2012) Clin. Sci. (Lond.) 122:143. Chiu, C.P. et al. (1988) Proc. Natl. Acad. Sci. USA 85:7099. Simpson, R.J. et al. (1988) Eur. J. Biochem. 176:187. Van Snick, J. et al. (1988) Eur. J. Immunol. 18:193. Murakami, M. et al. (1993) Science 260:1808. Muller-Newen, G. (2003) Sci. STKE 2003:PE40. Mitsuyama, K. et al. (2006) Clin. Exp. Immunol. 143:125. Cerutti, A. et al. (1998) J. Immunol. 160:2145.
Long Name	Interleukin 6
Entrez Gene IDs	3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 102138971 (Cynomolgus Monkey); 100034196 (Equine); 493687 (Feline); 463288 (Primate); 100008733 (Rabbit)
Alternate Names	B-cell differentiation factor, B-cell stimulatory factor 2, BSF-2, BSF2, CDF, CTL differentiation factor , HSF, IFN-beta-2, IFNB2, IL-6, IL6, Interferon beta-2, MGI-2A, hybridoma growth factor, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6

Citations for Recombinant Mouse IL-6 Protein (323)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Mouse IL-6 Protein include:

Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Ma et al. (2022), RORgammat phosphorylation protects against Tï¿½cell-mediated inflammation Cell Reports, 38(11):110520.
PMID: 35294872
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

B Czaya et al. (2022), Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling Elife, 11(0).
PMID: 35302487
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Yogev et al. (2022), CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector Tï¿½cell survival Cell Reports, 38(13):110565.
PMID: 35354043
Q Zhang et al. (2022), Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis JCI Insight, 7(3).
PMID: 35132955
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

FA Graca et al. (2022), The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy Nature Communications, 13(1):2370.
PMID: 35501350
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

YS Zhang et al. (2022), Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection Cell Death and Differentiation, 0(0).
PMID: 35614130
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Hayashi et al. (2022), MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis Cell Reports, 39(6):110805.
PMID: 35545056
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Mary et al. (2022), Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects Cancer Immunology Research, 0(0):OF1-OF17.
PMID: 35612500
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture

M Plana-Carm et al. (2022), The trophectoderm acts as a niche for the inner cell mass through C/EBPalpha-regulated IL-6 signaling Stem Cell Reports, 0(0).
PMID: 35961310
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LEA Damasceno et al. (2022), STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 39(8):110838.
PMID: 35613599
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HZ Yu et al. (2022), NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis Oncogene, 17(12):2765-2770.
PMID: 35662227
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LM Fan et al. (2022), Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation Oncogene, 108(0):108894.
PMID: 35729830
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Kamei et al. (2022), Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement Oncogene, 12(1):9243.
PMID: 35654941
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Navarrete et al. (2022), A cannabidiol aminoquinone derivative activates the PP2A/B55alpha/HIF pathway and shows protective effects in a murine model of traumatic brain injury Journal of Neuroinflammation, 19(1):177.
PMID: 35810304
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Su et al. (2022), hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype Journal of hematology oncology, 2022;15(1):99.
PMID: 35864538
Species: Mouse
Sample Types: Organoid
Applications: Bioassay

EC Freckmann et al. (2022), Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging Nature Communications, 13(1):5317.
PMID: 36085324
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Rani et al. (2022), IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 0(0).
PMID: 36074916
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Guo et al. (2022), IL6 supports long-term expansion of hepatocytes in vitro Nature Communications, 13(1):7345.
PMID: 36446858
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Scherlinge et al. (2022), Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity Science Advances, 8(48):eadc9657.
PMID: 36449620
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SA Park et al. (2022), Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 13(1):6069.
PMID: 36241625
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

X Liu et al. (2022), IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 0(0):e15631.
PMID: 36453131
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Hu et al. (2022), Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2 EBioMedicine, 86(0):104333.
PMID: 36335665
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Sripada et al. (2021), Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases PloS Biology, 19(3):e3001063.
PMID: 33684096
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

N Ohashi et al. (2021), GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS Scientific Reports, 11(1):12803.
PMID: 34140581
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Singh et al. (2021), Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells Scientific Reports, 11(1):11498.
PMID: 34075120
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Trilleaud et al. (2021), Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution Science Advances, 7(14).
PMID: 33811066
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Z Zheng et al. (2021), IL-6 Promotes the Proliferation and Immunosuppressive Function of Myeloid-Derived Suppressor Cells via the MAPK Signaling Pathway in Bladder Cancer BioMed Research International, 2021(0):5535578.
PMID: 33981768
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Zhou et al. (2021), m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Science Advances, 7(25).
PMID: 34134995
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Wang et al. (2021), MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF Cell Death and Differentiation, 0(0).
PMID: 34079078
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Basu et al. (2021), Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function Nature Immunology, 22(8):969-982.
PMID: 34312548
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Osman et al. (2021), TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer Nature Immunology, 0(0).
PMID: 34385712
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Yamamoto et al. (2021), A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells Cell Reports, 36(8):109576.
PMID: 34433054
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Zhou et al. (2021), The YAP/HIF-1&alpha/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation Cell bioscience, 2021;11(1):84.
PMID: 33980319
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Agasing et al. (2021), Interferon-beta Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease Cells, 10(8).
PMID: 34440908
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ML Chen et al. (2021), CAR directs T cell adaptation to bile acids in the small intestine Nature, 0(0).
PMID: 33828301
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Takashima et al. (2021), Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells Scientific Reports, 11(1):1520.
PMID: 33452355
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HZ Guo et al. (2021), Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis Science Advances, 7(41):eabg4167.
PMID: 34623912
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Dai et al. (2021), Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease Brain, Behavior, and Immunity, 98(0):337-348.
PMID: 34500034
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Contreras- et al. (2021), The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential Theranostics, 11(1):445-460.
PMID: 33391485
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Yoshizaki et al. (2021), Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/&beta1 integrin pathway Journal of Neuroinflammation, 18(1):12.
PMID: 33407620
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

S Droho et al. (2021), Macrophage-derived interleukin-6 is necessary and sufficient for choroidal angiogenesis Scientific Reports, 11(1):18084.
PMID: 34508129
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

J Mwirigi et al. (2021), A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist The journal of pain, 0(0).
PMID: 33429107
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Chauhan et al. (2021), Differential Cytokine-Induced Responses of Polarized Microglia Brain sciences, 11(11).
PMID: 34827481
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Liu et al. (2021), Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration Disease Models Mechanisms, 2021;14(12).
PMID: 34821368
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

FJ Velloso et al. (2021), Modestly increasing systemic interleukin-6 perinatally disturbs secondary germinal zone neurogenesis and gliogenesis and produces sociability deficits Brain, Behavior, and Immunity, 101(0):23-36.
PMID: 34954074
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Patel et al. (2021), Epigenetic drug ameliorated type 1 diabetes via decreased generation of Th1 and Th17 subsets and restoration of self-tolerance in CD4+ T cells International immunopharmacology, 103(0):108490.
PMID: 34954557
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Shi et al. (2021), The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons Journal of Neuroinflammation, 18(1):261.
PMID: 34749758
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Okubo et al. (2021), CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation International Journal of Molecular Sciences, 23(1).
PMID: 35008603
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

FRC Costa et al. (2021), NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes Cell Reports, 35(8):109176.
PMID: 34038731
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture

M Ichii et al. (2020), Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress Haematologica, 0(0).
PMID: 31974192
Species: Mouse

Applications: In Vivo

Z Hu et al. (2020), CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia Cell Rep, 31(7):107657.
PMID: 32433966
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Huang et al. (2020), Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity Nat. Cell Biol., 0(0).
PMID: 32367047
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

E Kumari et al. (2020), Developmental IL-6 Exposure Favors Production of PDGF-Responsive Multipotential Progenitors at the Expense of Neural Stem Cells and Other Progenitors Stem Cell Reports, 0(0).
PMID: 32302560
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Hirakata et al. (2020), Genetic Deletion of Socs3 in Smoothï¿½Muscle Cells Ameliorates Aorticï¿½Dissection in Mice JACC Basic Transl Sci, 5(2):126-144.
PMID: 32140621
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

RA Contreras- et al. (2020), PPAR&beta/&delta-dependent MSC metabolism determines their immunoregulatory properties Sci Rep, 10(1):11423.
PMID: 32651456
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Thapa et al. (2020), N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation Bioorg. Chem., 102(0):104095.
PMID: 32721777
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Kreutmair et al. (2020), Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model Leukemia, 0(0).
PMID: 32203142
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Lee et al. (2020), The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response J Neuroinflammation, 17(1):299.
PMID: 33054766
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

K Ozaki et al. (2020), Maternal immune activation induces sustained changes in fetal microglia motility Scientific Reports, 10(1):21378.
PMID: 33288794
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

MA Maqbool et al. (2020), Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation Cell Rep, 32(7):108048.
PMID: 32814051
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

K Makitani et al. (2020), STX-0119, a novel STAT3 dimerization inhibitor, prevents fibrotic gene expression in a mouse model of kidney fibrosis by regulating Cxcr4 and Ccr1 expression Physiol Rep, 8(20):e14627.
PMID: 33112058
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MJ Park et al. (2020), Myeloid-derived suppressor cells therapy enhance immunoregulatory properties in acute graft versus host disease with combination of regulatory T cells Journal of Translational Medicine, 18(1):483.
PMID: 33317573
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Girotra et al. (2020), In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro Int J Mol Sci, 21(21).
PMID: 33153113
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Pan et al. (2020), PPP2R2D suppresses interleukin-2 production and regulatory T cell function JCI Insight, 5(19).
PMID: 32897879
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

M Li et al. (2020), Quantification of Citrullinated Histone H3 Bound DNA for Detection of Neutrophil Extracellular Traps Cancers (Basel), 12(11).
PMID: 33218159
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

IS Massart et al. (2020), Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia Cancers (Basel), 12(11).
PMID: 33142864
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

H Zhang et al. (2020), An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets Cell Rep, 33(8):108433.
PMID: 33238123
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Zhou et al. (2020), Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation JCI Insight, 0(0).
PMID: 32027619
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Ma et al. (2020), Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation Cell Rep, 30(3):793-806.e6.
PMID: 31968254
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Yoshimi et al. (2020), Genetic basis for iMCD-TAFRO Oncogene, 0(0).
PMID: 32051554
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

YM Hyun et al. (2020), Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation Sci Adv, 6(45).
PMID: 33158867
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Baniahmad et al. (2020), The frequency of follicular T helper cells differs in acute and chronic neuroinflammation Sci Rep, 10(1):20485.
PMID: 33235306
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Liu et al. (2020), ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation Cell. Mol. Immunol., 0(0).
PMID: 32572163
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Hong et al. (2020), Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System Biomedicines, 8(12).
PMID: 33317212
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TT Tang et al. (2020), Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI Sci Adv, 6(33):eaaz0748.
PMID: 32851154
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MA Maqbool et al. (2020), Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation Cell Rep, 32(7):108048.
PMID: 32814051
Species: Mouse
Sample Types: Whole Tissue

J Jhun et al. (2020), Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells J Transl Med, 18(1):317.
PMID: 32799896
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

B Zwarycz et al. (2019), IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model Cell Mol Gastroenterol Hepatol, 7(1):1-17.
PMID: 30364840
Species: Mouse
Sample Types: In Vivo

E Minakova et al. (2019), Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism PLoS ONE, 14(1):e0210389.
PMID: 30629642
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KL Graham et al. (2019), DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 30718413
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Yasuda et al. (2019), Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 10(1):549.
PMID: 30710091
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Funk et al. (2019), The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 Sci Rep, 9(1):4515.
PMID: 30872638
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

H Katsura et al. (2019), IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration Stem Cell Reports, 0(0).
PMID: 30930244
Species: Mouse

Applications: Cell Culture

S Das et al. (2019), BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis Oncogene, 0(0).
PMID: 30635655
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

F Ribezzo et al. (2019), Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome Leukemia, 0(0).
PMID: 30651631
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Li et al. (2019), Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells Arthritis Res. Ther., 21(1):105.
PMID: 31023362
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Li et al. (2019), Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC Haematologica, 0(0).
PMID: 30975912
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Abdullah et al. (2019), Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis PLoS ONE, 14(4):e0215981.
PMID: 31026283
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

C Lao et al. (2019), 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORÎ³t Bioorg. Chem., 90(0):103077.
PMID: 31323598
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JQ Yang et al. (2019), Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation J. Leukoc. Biol., 0(0).
PMID: 31260596
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Ondee et al. (2019), Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice Cells, 8(9).
PMID: 31514375
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

MD Powell et al. (2019), IL-12 signaling drives the differentiation and function of a TH1-derived TFH1-like cell population Sci Rep, 9(1):13991.
PMID: 31570752
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

W Zhou et al. (2019), Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection Cells, 8(10).
PMID: 31623153
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Standard

J Yu et al. (2019), Serum amyloid A-mediated inflammasome activation of microglial cells in cerebral ischemia J. Neurosci., 0(0).
PMID: 31611307
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Pham et al. (2019), Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf Cell Rep, 29(5):1203-1220.e7.
PMID: 31665634
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Mahmoudi et al. (2019), Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing Nature, 574(7779):553-558.
PMID: 31645721
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

T Fukushima et al. (2019), Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium Cell Rep, 29(12):4144-4158.e7.
PMID: 31851939
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

F Wang et al. (2019), Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLL?AF9 translocation Mol Med Rep, 0(0).
PMID: 31789407
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

M Li et al. (2019), Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17?cell response in mice Microb. Pathog., 138(0):103826.
PMID: 31676364
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

DS Kim et al. (2019), Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition Mediators Inflamm., 2019(0):5648987.
PMID: 31780863
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

T Hasegawa et al. (2019), Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1 Nat. Immunol., 20(12):1631-1643.
PMID: 31740799
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

X Zhou et al. (2019), 3?-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation J Immunol Res, 2019(0):2431617.
PMID: 31240232
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JV Pearce et al. (2019), E0771 and 4T1 murine breast cancer cells and interleukin 6 alter gene expression patterns but do not induce browning in cultured white adipocytes Biochem Biophys Rep, 18(0):100624.
PMID: 31193642
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CC Hsieh et al. (2018), Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice Stem Cell Res Ther, 9(1):183.
PMID: 29973247
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

P Barragán-I et al. (2018), Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice Nat Commun, 9(1):10.
PMID: 29295980
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Yang et al. (2018), Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway Stem Cell Res Ther, 9(1):62.
PMID: 29523215
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JE Draper et al. (2018), A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects PLoS Genet., 14(1):e1007127.
PMID: 29300724
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KL Garner et al. (2018), Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress Sci Rep, 8(1):3902.
PMID: 29500363
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

YY Wang et al. (2018), In vivo selection with lentiviral expression of Bcl2T69A/S70A/S87Amutant in hematopoietic stem cell-transplanted mice Gene Ther., 0(0).
PMID: 29523881
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Lee et al. (2018), Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist PLoS ONE, 13(2):e0193086.
PMID: 29481574
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Nam et al. (2018), Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis PLoS ONE, 13(6):e0198740.
PMID: 29879214
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Sun et al. (2018), Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulatingadipose stromal interleukin 6 production in mice J. Biol. Chem., 0(0).
PMID: 29298894
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Archer-Lah et al. (2018), Physiological culture conditions alter myotube morphology and responses to atrophy treatments: implications for inï¿½vitro research on muscle wasting Physiol Rep, 6(12):e13726.
PMID: 29932505
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SK Varanasi et al. (2018), Hexokinase II may be dispensable for CD4 T cell responses against a virus infection PLoS ONE, 13(1):e0191533.
PMID: 29352298
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HA Ting et al. (2018), Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection Mucosal Immunol, 0(0).
PMID: 30038214
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HC Chuang et al. (2018), GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease Sci Adv, 4(9):eaat5401.
PMID: 30214937
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

A Badamchi-Z et al. (2018), Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy J. Immunol., 0(0).
PMID: 30249811
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

CM Percopo et al. (2018), Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection J. Immunol., 0(0).
PMID: 30578308
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Gilleron et al. (2018), Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance Cell Rep, 25(12):3329-3341.e5.
PMID: 30566860
Species: Mouse
Sample Types: Recombinant Protein
Applications: ELISA (Standard)

F Dou et al. (2018), EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-?B signaling pathway Mol Brain, 11(1):75.
PMID: 30563578
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Engelowski et al. (2018), IL-23R Signaling Plays No Role in Myocardial Infarction Sci Rep, 8(1):17078.
PMID: 30459442
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KA de Lima et al. (2018), TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism Cell Death Dis, 9(11):1130.
PMID: 30425241
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Amir et al. (2018), REV-ERB? Regulates TH17 Cell Development and Autoimmunity Cell Rep, 25(13):3733-3749.e8.
PMID: 30590045
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

W Klement et al. (2018), Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature Neurobiol. Dis., 0(0).
PMID: 29432809
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Meyer Zu H et al. (2018), Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1 Immunity, 48(3):556-569.e7.
PMID: 29562202
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Zhang et al. (2018), Celastrol mediates Th17 and Treg cell generation via metabolic signaling Biochem. Biophys. Res. Commun., 0(0).
PMID: 29476742
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JA Johnson et al. (2018), Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium Biol Open, 7(4).
PMID: 29661797
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Nagase et al. (2018), Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation J. Exp. Med., 0(0).
PMID: 29643185
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Q Zhao et al. (2017), Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota J. Immunol., 0(0).
PMID: 28539431
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Hu et al. (2017), Armc5 deletion causes developmental defects and compromises T-cell immune responses Nat Commun, 8(0):13834.
PMID: 28169274
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Hara et al. (2017), Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury Nat. Med., 0(0).
PMID: 28628111
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Fernández et al. (2017), Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming Eur. J. Immunol., 0(0).
PMID: 28762472
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Franchi et al. (2017), Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis J. Immunol, 0(0).
PMID: 28242647
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

JK Moy et al. (2017), The MNK - eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain J. Neurosci., 0(0).
PMID: 28674170
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Liu et al. (2017), Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis Gastroenterol Res Pract, 2017(0):3089378.
PMID: 28584524
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Ouzounova et al. (2017), Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade Nat Commun, 8(0):14979.
PMID: 28382931
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MA L‚cuyer et al. (2017), Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis Proc. Natl. Acad. Sci. U.S.A, 114(4):E524-E533.
PMID: 28069965
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z You et al. (2017), BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway Eur. J. Immunol., 0(0).
PMID: 28681958
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Kang et al. (2017), BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis Biol. Res, 50(1):8.
PMID: 28241881
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TM Nordmann et al. (2017), The Role of Inflammation in ?-cell Dedifferentiation Sci Rep, 7(1):6285.
PMID: 28740254
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Jiang et al. (2017), Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia Nat Commun, 8(1):2099.
PMID: 29235481
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Fu et al. (2017), Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1 J. Exp. Med., 0(0).
PMID: 28400474
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Hosokawa et al. (2017), Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function J. Immunol., 0(0).
PMID: 28768723
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Hammer et al. (2017), Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation J Neuroinflammation, 14(1):184.
PMID: 28899400
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SH Lee et al. (2017), Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis Sci Rep, 7(1):10133.
PMID: 28860618
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Pan et al. (2017), The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells Parasit Vectors, 10(1):348.
PMID: 28732522
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Downs-Cann et al. (2017), Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells Nat Commun, 8(0):14649.
PMID: 28290453
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Shukla et al. (2017), Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 14(5):531-538.
PMID: 28394335
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Tamehiro et al. (2017), T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation Immunol. Cell Biol., 0(0).
PMID: 28462950
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Li et al. (2017), IL-23 restoration of Th17 effector function is independent of IL-6 and TGF-? in a mouse model of alcohol and burn injury J. Leukoc. Biol., 0(0).
PMID: 28684599
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HP Thu Le et al. (2017), The frequency of Th17ï¿½cells in the small intestine exhibits a day-night variation dependent on circadian clock activity Biochem. Biophys. Res. Commun., 0(0).
PMID: 28619514
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Xu et al. (2017), Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance Nat Commun, 8(0):14803.
PMID: 28466852
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Li et al. (2017), Dendritic cell MST1 inhibits Th17 differentiation Nat Commun, 8(0):14275.
PMID: 28145433
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

K Timper et al. (2017), IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling Cell Rep, 19(2):267-280.
PMID: 28402851
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KA Read et al. (2017), Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells J. Immunol., 0(0).
PMID: 28848064
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AA Kesewa Lay et al. (2017), Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production Sci Rep, 7(0):39649.
PMID: 28051111
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Eichler et al. (2017), Mï¿½ller Cell-Derived PEDF Mediates Neuroprotection via STAT3 Activation Cell. Physiol. Biochem., 44(4):1411-1424.
PMID: 29186716
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Akbar et al. (2017), Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction JCI Insight, 2(17).
PMID: 28878126
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Chen et al. (2017), mTORC2 controls Th9 polarization and allergic airway inflammation Allergy, 0(0).
PMID: 28273354
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CX Yi et al. (2017), TNF? drives mitochondrial stress in POMC neurons in obesity Nat Commun, 8(0):15143.
PMID: 28489068
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

S Ollila et al. (2017), Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway J. Clin. Invest., 0(0).
PMID: 29202476
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

QH Wang et al. (2017), Pharmacological Effect ofCaulophyllum robustumon Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-?B, and Proinflammatory Cytokines In Vivo and In Vitro Evid Based Complement Alternat Med, 2017(0):8134321.
PMID: 29456573
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Muschaweck et al. (2017), IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells J. Immunol., 0(0).
PMID: 28855314
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Huang et al. (2017), Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease Mol Ther Methods Clin Dev, 5(0):241-258.
PMID: 28603745
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Zhang et al. (2017), Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation Sci Rep, 7(0):41887.
PMID: 28165507
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Zhang et al. (2017), The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury Cell Death Dis, 8(3):e2695.
PMID: 28333137
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Oike et al. (2017), Stat3 as a potential therapeutic target for rheumatoid arthritis Sci Rep, 7(1):10965.
PMID: 28887478
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MH Ross et al. (2017), Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases Cancer Res., 0(0).
PMID: 28855208
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Oh-Oka et al. (2017), Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor Cell Mol Gastroenterol Hepatol, 4(1):135-151.
PMID: 28593185
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells J Immunol, 196(11):4731-8.
PMID: 27183613
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1 Cytokine, 82(0):58-69.
PMID: 26748724
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins Nat. Med., 22(6):672-8.
PMID: 27135740
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Elaine Fuchs (2016), Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin Cell, 167(5):1323-1338.e14.
PMID: 27863246
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Sci Rep, 6(0):37977.
PMID: 27905482
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lee J et al. (2016), RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis. J Neuroinflammation, 13(1):24.
PMID: 26831924
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency Stem Cell Reports, 0(0).
PMID: 27453007
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BW Li et al. (2016), T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice Eur J Immunol, 0(0).
PMID: 27062360
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Emma L Rawlins (2016), Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate Development, 143(20):3686-3699.
PMID: 27578791
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

I Meininger et al. (2016), Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells Nat Commun, 7(0):11292.
PMID: 27068814
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Bioassay

Jung-Yeon Lim (2016), Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis Sci Rep, 6(0):26851.
PMID: 27246365
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity Eur J Immunol, 0(0).
PMID: 27222115
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ian P Salt (2016), Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation Mol. Cell. Endocrinol., 0(0).
PMID: 27840174
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Renalase expression by melanoma and tumor associated-macrophages promotes tumor growth through a STAT3-mediated mechanism Cancer Res, 0(0).
PMID: 27197188
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LN Guthrie et al. (2016), Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses J. Biol. Chem., 291(30):15830-40.
PMID: 27226638
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), The role of local IL6/JAK2/STAT3 signaling in high glucose-induced podocyte hypertrophy Kidney Res Clin Pract, 35(4):212-218.
PMID: 27957415
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shweta Pasi (2016), Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response J Biol Chem, 291(23):12358-69.
PMID: 27022030
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2 Cancer Discov, 0(0).
PMID: 27630126
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sasaki C et al. (2016), p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice. Eur J Immunol, 46(1):212-22.
PMID: 26514620
Species: Mouse
Sample Types: Complex Sample Type
Applications: Bioassay

Anna Daria (2016), Young microglia restore amyloid plaque clearance of aged microglia EMBO J, 0(0).
PMID: 28007893
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor ?1 expression Stem Cell Res Ther, 7(1):175.
PMID: 27906099
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Matthes T et al. (2015), Autocrine amplification of immature myeloid cells by IL-6 in multiple myeloma-infiltrated bone marrow. Leukemia, 29(9):1882-90.
PMID: 26159051
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Seto D et al. (2015), A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia. J Biol Chem, 290(32):19976-86.
PMID: 26092726
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Klimatcheva E et al. (2015), CXCL13 antibody for the treatment of autoimmune disorders. BMC Immunol, 16(0):6.
PMID: 25879435
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Basu R et al. (2015), IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol, 16(3):286-95.
PMID: 25642823
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Annemann M et al. (2015), IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection. J Immunol, 194(6):2888-98.
PMID: 25694610
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wang F et al. (2015), Mouse Resistin (mRetn): cloning, expression and purification in Escherichia coli and the potential regulative effects on murine bone marrow hematopoiesis. BMC Biotechnol, 15(0):105.
PMID: 26572487
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lee H et al. (2015), Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells. J Immunol, 194(8):3634-45.
PMID: 25769927
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Haftmann C et al. (2015), miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol, 45(4):1192-205.
PMID: 25486906
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Monin L et al. (2015), Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge. Mucosal Immunol, 8(5):1099-109.
PMID: 25627812
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Schwinge D et al. (2015), Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. J Immunol, 194(6):2522-30.
PMID: 25672751
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Iriguchi S et al. (2015), T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung. Blood, 125(2):370-82.
PMID: 25349175
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rutz S et al. (2015), Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature, 518(7539):417-21.
PMID: 25470037
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Oshida K et al. (2015), Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) in a mouse liver gene expression compendium. PLoS ONE, 10(2):e0112655.
PMID: 25689681
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Solt L et al. (2015), ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes. Endocrinology, 156(3):869-81.
PMID: 25560829
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Gopinathan G et al. (2015), Interleukin-6 Stimulates Defective Angiogenesis. Cancer Res, 75(15):3098-107.
PMID: 26081809
Species: Mouse
Sample Types: Cell Lysates
Applications: ELISA (Standard)

Yang L et al. (2015), KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest, 125(4):1620-36.
PMID: 25751064
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Buckley M et al. (2015), ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers. J Immunol, 194(4):1665-76.
PMID: 25595778
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ding Q et al. (2015), Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORgammat Activity and Suppressing Th17 Cell Differentiation. PLoS ONE, 10(9):e0137711.
PMID: 26368822
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chandler et al. (2015), Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat Commun, 6(0):6118.
PMID: 25625625
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Illert et al. (2015), Grb10 is involved in BCR-ABL-positive leukemia in mice. Leukemia, 29(4):858-68.
PMID: 25249015
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chung et al. (2014), Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion. J Immunol, 192(6):2593-601.
PMID: 24532581
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yang C et al. (2014), Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol, 192(4):1547-57.
PMID: 24403530
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Reynolds C et al. (2014), Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile. BMC Biol, 12(0):32.
PMID: 24886643
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Neumann C et al. (2014), Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med, 211(9):1807-19.
PMID: 25073792
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ramkhelawon B et al. (2014), Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med, 20(4):377-84.
PMID: 24584118
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Buckley M et al. (2014), Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation. PLoS ONE, 9(8):e105576.
PMID: 25153088
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu Y et al. (2014), Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol, 192(1):59-72.
PMID: 24323580
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fujihara Y et al. (2014), Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration. Stem Cells, 32(5):1208-19.
PMID: 24446149
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Mauer J et al. (2014), Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol, 15(5):423-30.
PMID: 24681566
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA (Standard)

Ingham V et al. (2014), Glimepiride reduces CD14 expression and cytokine secretion from macrophages. J Neuroinflammation, 11(0):115.
PMID: 24952384
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim H et al. (2014), Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function. PLoS ONE, 9(4):e95332.
PMID: 24743300
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yeste A et al. (2014), IL-21 induces IL-22 production in CD4+ T cells. Nat Commun, 5(0):3753.
PMID: 24796415
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hahn W et al. (2014), Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Am J Physiol Endocrinol Metab, 306(9):E1033-45.
PMID: 24595304
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Knudsen J et al. (2014), Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue. PLoS ONE, 9(1):e84910.
PMID: 24416310
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tadokoro et al. (2014), IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. Proc Natl Acad Sci U S A, 111(35):E3641-9.
PMID: 25136113
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wan J et al. (2014), M2 kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease. Am J Pathol, 184(6):1763-72.
PMID: 24713392
Species: N/A
Sample Types: Complex Sample Type
Applications: Bioassay

Gupta et al. (2014), Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J Biol Chem, 289(12):8706-19.
PMID: 24415766
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhu E et al. (2014), miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3. J Immunol, 192(12):5599-609.
PMID: 24842756
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA (Standard)

Speck S et al. (2014), TGF-beta signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation. PLoS ONE, 9(7):e102390.
PMID: 25072375
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu X et al. (2014), The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation. PLoS ONE, 9(8):e104906.
PMID: 25119106
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Meares G et al. (2014), PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Mol Cell Biol, 34(20):3911-25.
PMID: 25113558
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Janelsins et al. (2014), Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity. Proc Natl Acad Sci U S A, 111(1):373-8.
PMID: 24344308
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Suresh Babu S et al. (2014), TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer, 14(0):113.
PMID: 24555435
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Mayeur et al. (2014), The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Blood, 123(14):2261-8.
PMID: 24501215
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Teramachi J et al. (2014), Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone. J Bone Miner Res, 29(6):1456-65.
PMID: 24339057
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nakahara F et al. (2014), Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood, 123(25):3932-42.
PMID: 24825862
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tatano Y et al. (2014), Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization. Sci Rep, 4(0):4146.
PMID: 24553452
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ikeda T et al. (2014), Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells. PLoS ONE, 9(12):e115198.
PMID: 25522369
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nunez S et al. (2013), T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour. Immunology, 139(1):61-71.
PMID: 23278668
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bancerek J et al. (2013), CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity, 38(2):250-62.
PMID: 23352233
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mascanfroni et al. (2013), IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol, 14(10):1054-63.
PMID: 23995234
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Schmid M et al. (2013), PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth. PLoS ONE, 8(4):e60226.
PMID: 23565202
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Stephens G et al. (2013), Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol, 43(7):1727-34.
PMID: 23568529
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pereira C et al. (2013), Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell, 13(2):205-18.
PMID: 23770078
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lee J et al. (2013), Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase. PLoS ONE, 8(4):e60900.
PMID: 23613752
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cho S et al. (2013), The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone. J Biol Chem, 288(10):6814-25.
PMID: 23297399
Ramachandran et al. (2013), Myeloid-derived suppressor cells regulate growth of multiple myeloma by inhibiting T cells in bone marrow. J Immunol, 190(7):3815-23.
PMID: 23460744
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yamamizu K et al. (2013), Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports, 1(6):545-59.
PMID: 24371809
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Choi S et al. (2013), Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia. J Exp Med, 210(3):551-61.
PMID: 23401489
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yanaba K et al. (2013), Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J Leukoc Biol, 94(4):563-73.
PMID: 23630391
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

van Voorhis et al. (2013), Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. PLoS ONE, 8(12):e82545.
PMID: 24349309
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Lee S et al. (2013), Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production. PLoS ONE, 8(12):e80873.
PMID: 24324641
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Park J et al. (2013), p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice. Arthritis Rheum, 65(4):949-59.
PMID: 23280308
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hanieh H et al. (2013), MicroRNA-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration. Eur J Immunol, 43(10):2771-82.
PMID: 23780851
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Quinton LJ et al. (2012), Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice. J. Clin. Invest., 122(5):1758-63.
PMID: 22466650
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu N et al. (2012), Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression. Mol. Endocrinol., 26(5):775-85.
PMID: 22474109
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Loh KC et al. (2012), Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS ONE, 7(5):e37218.
PMID: 22606352
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Nakasone Y et al. (2012), Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma. Am. J. Pathol., 180(1):365-74.
PMID: 22037251
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Roy M et al. (2012), CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. J Neuroinflammation, 9(0):18.
PMID: 22269426
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2012), Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat. Med., 1248(0):18.
PMID: 22772464
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Michel M et al. (2012), Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells. Proc Natl Acad Sci U S A, 109(43):17549-54.
PMID: 23047700
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2012), Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 109(25):9971-6.
PMID: 22665806
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bruchard M et al. (2012), Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med, 19(1):57-64.
PMID: 23202296
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tormo AJ et al. (2012), IL-6 activates STAT5 in T cells. Cytokine, 60(0):575.
PMID: 22854263
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jones GW et al. (2011), Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J., 25(1):409-19.
PMID: 20826539
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jin W et al. (2011), The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function. BMC Immunol., 12(0):68.
PMID: 22182253
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

El-Behi M et al. (2011), The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 12(6):568-75.
PMID: 21516111
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nakahama T et al. (2011), Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis. Proc. Natl. Acad. Sci. U.S.A., 108(34):14222-7.
PMID: 21825138
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cao W et al. (2011), Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity, 35(2):273-84.
PMID: 21835648
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cook BD et al. (2011), Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood, 117(24):6489-97.
PMID: 21515822
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ma Y et al. (2011), Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J. Exp. Med., 208(3):491-503.
PMID: 21383056
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tan C et al. (2010), Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site. J. Immunol., 185(11):6795-801.
PMID: 20971929
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yoshizaki A et al. (2010), Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J. Immunol., 185(4):2502-15.
PMID: 20624949
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Boenisch O et al. (2010), TIM-3: a novel regulatory molecule of alloimmune activation. J. Immunol., 185(10):5806-19.
PMID: 20956339
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jones GW et al. (2010), Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J. Immunol., 184(4):2130-9.
PMID: 20083667
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Kayamuro H et al. (2010), Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 84(24):12703-12.
PMID: 20881038
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chen G et al. (2010), Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel. J. Immunol., 185(4):2350-9.
PMID: 20639489
Species: Mouse
Sample Types: Buffer
Applications: Western Blot

Martin U et al. (2009), Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages. J. Immunol., 183(6):4021-30.
PMID: 19717513
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Osuchowski MF et al. (2009), Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit. Care Med., 37(5):1567-73.
PMID: 19325479
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Banerjee I et al. (2009), IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart. Am. J. Physiol. Heart Circ. Physiol., 296(5):H1694-704.
PMID: 19234091
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Nilsberth C et al. (2009), The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2. Endocrinology, 150(4):1850-60.
PMID: 19022895
Wieland CW et al. (2009), ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect., 11(4):524-30.
PMID: 19286469
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sehrawat S et al. (2009), Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J. Immunol., 182(5):3191-201.
PMID: 19234217
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ghiringhelli F et al. (2009), Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat. Med., 15(10):1170-8.
PMID: 19767732
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chen X et al. (2009), Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway. J. Immunol., 183(10):6135-44.
PMID: 19841165
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Dienz O et al. (2009), The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med., 206(1):69-78.
PMID: 19139170
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Thomay AA et al. (2009), Disruption of interleukin-1 signaling improves the quality of wound healing. Am. J. Pathol., 174(6):2129-36.
PMID: 19389930
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Wieland CW et al. (2008), CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology, 125(2):272-9.
PMID: 18393969
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shinohara ML et al. (2008), Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity, 29(1):68-78.
PMID: 18619869
Gohda M et al. (2008), Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J. Immunol., 180(8):5335-43.
PMID: 18390715
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Kida H et al. (2008), GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am. J. Pathol., 172(6):1542-54.
PMID: 18467707
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Muranski P et al. (2008), Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood, 112(2):362-73.
PMID: 18354038
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

McKinley L et al. (2008), TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 181(6):4089-97.
PMID: 18768865
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ohba T et al. (2008), A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum., 58(11):3510-9.
PMID: 18975342
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Guo B et al. (2008), The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 118(5):1680-90.
PMID: 18382764
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fenton JI et al. (2008), Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells. Int. J. Cancer, 122(11):2437-45.
PMID: 18338750
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cox CA et al. (2008), Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J. Immunol., 180(11):7414-22.
PMID: 18490741
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Boesen EI et al. (2007), Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice. Am. J. Physiol. Heart Circ. Physiol., 293(3):H1745-9.
PMID: 17557918
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Vazquez JF et al. (2007), Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study. J. Neurochem., 105(3):904-9.
PMID: 18088370
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Riou S et al. (2007), High pressure promotes monocyte adhesion to the vascular wall. Circ. Res., 100(8):1226-33.
PMID: 17395876
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu SJ et al. (2007), Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J. Leukoc. Biol., 82(2):354-60.
PMID: 17505023
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yamaguchi Y et al. (2007), IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. J. Immunol., 179(10):7128-36.
PMID: 17982105
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhu J et al. (2007), Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood, 109(9):3706-12.
PMID: 17227831
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kurooka M et al. (2007), Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells. Cancer Res., 67(1):227-36.
PMID: 17210703
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Smith SE et al. (2007), Maternal immune activation alters fetal brain development through interleukin-6. J. Neurosci., 27(40):10695-702.
PMID: 17913903
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Meagher MW et al. (2007), Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler's virus infection. Brain Behav. Immun., 21(8):1083-95.
PMID: 17591434
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

McGeachy MJ et al. (2007), TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol., 8(12):1390-7.
PMID: 17994024
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Gao H et al. (2006), Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J. Immunol., 177(1):612-20.
PMID: 16785559
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Osuchowski MF et al. (2006), Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 177(3):1967-74.
PMID: 16849510
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Perl M et al. (2006), The pulmonary and hepatic immune microenvironment and its contribution to the early systemic inflammation following blunt chest trauma. Crit. Care Med., 34(4):1152-9.
PMID: 16484915
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

An HJ et al. (2006), Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. J Ethnopharmacol, 106(3):418-24.
PMID: 16530364
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bettelli E et al. (2006), Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 441(7090):235-8.
PMID: 16648838
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Braun BS et al. (2006), Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood, 108(6):2041-4.
PMID: 16720837
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yilmaz OH et al. (2005), SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood, 107(3):924-30.
PMID: 16219798
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Niederkofler V et al. (2005), Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J. Clin. Invest., 115(8):2180-6.
PMID: 16075058
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Costa SK et al. (2005), Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature. J. Neuroimmunol., 171(1):99-109.
PMID: 16269189
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Fredj S et al. (2005), Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation. J. Cell. Physiol., 204(2):428-36.
PMID: 15717324
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Osuchowski MF et al. (2005), Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 302(1):172-81.
PMID: 16023134
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Ellaban E et al. (2004), Selective macrophage suppression during sepsis. Cell. Immunol., 231(1):103-11.
PMID: 15919375
Species: N/A
Sample Types: N/A
Applications: Western Blot

Gard AL et al. (2004), Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience, 127(1):43-52.
PMID: 15219667
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Banerjee K et al. (2004), CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization. J. Immunol., 172(2):1237-45.
PMID: 14707102
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gyotoku E et al. (2001), The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch. Dermatol. Res., 293(10):508-14.
PMID: 11820727
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Liu F et al. (1997), Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood, 90(7):2583-90.
PMID: 9326224

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Recombinant Mouse IL-6 Protein

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