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Recombinant Human TROY/TNFRSF19 Fc Chimera Protein, CF

Bio-Techne includes R&D Systems | Catalog # 1548-TR

Catalog #
Size / Price

Key Product Details



Accession #

Structure / Form

Disulfide-linked homodimer





Product Specifications


Mouse myeloma cell line, NS0-derived human TROY/TNFRSF19 protein
Human TROY
Accession # AAF71828
N-terminus C-terminus


>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<0.01 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis


Predicted Molecular Mass

42 kDa (monomer)


50-55 kDa, reducing conditions


Measured by its binding ability in a functional ELISA.
When Recombinant Human Lgr5/GPR49 Fc Chimera (Catalog # 8078-GP) is coated at 0.5 μg/mL, Recombinant Human TROY/TNFRSF19 Fc Chimera binds with an apparent Kd <500 nM.

Formulation, Preparation and Storage

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitute at 100 μg/mL in sterile PBS.

Reconstitution Buffer Available:
Size / Price
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TROY/TNFRSF19

TROY (also known as TAJ and TNFRSF19) is a 45‑55 kDa member of the TNF receptor superfamily of molecules (1‑4). It is widely expressed in the embryo, but shows limited expression in adult. In particular, embryonic TROY is found in embryonic epithelium, neural tube, and mesenchyme, and developing neurons of the hippocampus and thalamus (5, 6). In the adult, TROY is found in the nervous system associated with dorsal root and retinal ganglia neurons, astrocytes, and microglia, and in hair follicles where it is expressed by dermal papilla matrix cells (4, 7, 8, 9). In human, TROY has also been found on melanoma cells, not normal melanocytes (10). TROY is reportedly a component of the Nogo-A receptor, taking the place of p75 in a membrane-bound LINGO-1:NgR1:TROY complex (6, 8, 9). This complex purportedly mediates axon repulsion initiated by one of five myelin-associated inhibitory factors (OMpg; CD100; Ephrin B3; Nogo-A; MAG) (6, 11). In the hair follicle, TROY binds LTa and acts with Eda to drive secondary hair follicle development (4, 12). Mature human TROY is a 394 amino acid (aa) type I transmembrane protein (1‑3). It possesses a 141 aa extracellular region (aa 30‑170) that contains three 40 aa TNFR cysteine motifs, and an extended 232 aa cytoplasmic domain (aa 192‑423). There is one potential isoform that shows a two aa substitution for aa 416‑423. The extracellular domains of human and mouse TROY share 90% aa identity.


  1. Hu, S. et al. (1999) Genomics 62:103.
  2. Eby, M.T. et al. (2000) J. Biol. Chem. 275:15336.
  3. Kojima, T. et al. (2000) J. Biol. Chem. 275:20742.
  4. Hashimoto, T. et al. (2008) Cell Cycle 7:106.
  5. Pispa, J. et al. (2003) Gene Exp. Patterns 3:675.
  6. Mi, S. (2008) Cytokine Growth Factor Rev. 19:245.
  7. Satoh, J. et al. (2007) Neuropathol. Appl. Neurobiol. 33:99.
  8. Shao, Z. et al. (2005) Neuron 45:353.
  9. Park, J.B. et al. (2000) Neuron 45:345.
  10. Spanjaard, R.A. et al. (2007) Int. J. Cancer 120:1304.
  11. Venkatesh, K. et al. (2007) J. Cell Biol. 177:393.
  12. Pispa, J. et al. (2008) Hum. Mol. Genet. 17:3380.

Long Name

Tumor Necrosis Factor Receptor Superfamily, Member 19

Alternate Names


Entrez Gene IDs

55504 (Human); 29820 (Mouse)

Gene Symbol



Additional TROY/TNFRSF19 Products

Product Documents for Recombinant Human TROY/TNFRSF19 Fc Chimera Protein, CF

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Recombinant Human TROY/TNFRSF19 Fc Chimera Protein, CF

For research use only

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Reconstitution Calculator

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