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Recombinant Human TRANCE/RANK L/TNFSF11 Protein

Catalog # 390-TN | R&D Systems, Inc. a Bio-Techne Brand
A New rh TRANCE is Now Available! The new protein has no tag!
Graph showing dose-dependent bioactivity of Human TRANCE protein
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With Carrier
390-TN-010

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Carrier Free
390-TN-010/CF
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Setting the standard in quality research reagents

Key Product Details

Source: NS0
Accession #: AAC51762
Applications: Bioactivity

Citations for Recombinant Human TRANCE/RANK L/TNFSF11 Protein (39)

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Customer Reviews for Recombinant Human TRANCE/RANK L/TNFSF11 Protein (8)

4.8 out of 5
8 customer ratings
5 stars
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  • Recombinant Human TRANCE/RANK L/TNFSF11 Protein
    Name: Zijun Zhang
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 05/17/2022
    Recombinant Human TRANCE/RANK L/TNFSF11 Protein In vitro bioactivity in cell culture 390-TN
  • Recombinant Human TRANCE/RANK L/TNFSF11 Protein
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Reason for Rating: Steady quality! 60 ng/ml RANKL can induce monocyte to osteoclast very well.
    Verified Customer | Posted 12/31/2021
    Recombinant Human TRANCE/RANK L/TNFSF11 Protein In vitro bioactivity in cell culture 390-TN
  • Recombinant Human TRANCE/RANK L/TNFSF11 Protein
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Reason for Rating: 50ng/ml RANKL is good for induce the human monocyte to osteoclast.
    Verified Customer | Posted 03/20/2021
    Recombinant Human TRANCE/RANK L/TNFSF11 Protein In vitro bioactivity in cell culture 390-TN
  • Recombinant Human TRANCE/RANK L/TNFSF11 Protein
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Reason for Rating: 50ng/ml RANKL, 25ng/ml M-CSF in a-MEM works well for human osteoclasts.
    Verified Customer | Posted 01/18/2021
    Recombinant Human TRANCE/RANK L/TNFSF11 Protein In vitro bioactivity in cell culture 390-TN
  • Name: Vaishali Sarode
    Application: CellProlif
    Verified Customer | Posted 02/06/2019
  • Recombinant Human TRANCE/RANK L/TNFSF11 Protein
    Name: Anonymous
    Application: Characterization by MS
    Verified Customer | Posted 01/05/2018
    Recombinant Human TRANCE/RANK L/TNFSF11 Protein Other 390-TN
  • Name: Abby Sukarto
    Verified Customer | Posted 05/16/2017
  • Recombinant Human TRANCE/RANK L/TNFSF11 Protein
    Name: preety panwar
    Application: CellProlif
    Verified Customer | Posted 05/18/2016
    Recombinant Human TRANCE/RANK L/TNFSF11 Protein Cell Proliferation 390-TN

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FAQs for Recombinant Human TRANCE/RANK L/TNFSF11 Protein

  • This protein datasheet indicates I need to use a cross-linking antibody, Catalog # MAB050, for biological activity. What is this antibody and is it really necessary?

    The antibody is directed against a 6x histidine repeat and is recommended for use as a cross-linker of proteins with 6x his-tag. Crosslinking is often used for proteins that require receptor trimerization and can result greater biological activity. R&D Systems Quality Control tests the performance of these proteins in the presence of the cross-linking antibody. Therefore, it is necessary to use this antibody when trying to achieve the same level of specific activity described in the datasheet.

  • Is this protein provided in trimeric form or monomer form? 

    We do not define this protein as being exclusively a monomer, but we know that the protein is not fully associated into trimers because we need to use a cross-linking antibody for our in-house activity testing to cause multiple subunits of this protein to associate. This product has been shown to be biologically active in such testing when a cross-linking antibody is used. Therefore, we would expect for this protein to perform its expected biological function.

  • What are the differences between the Recombinant Human TRANCE/RANK L/TNFSF11 Protein (Catalog # 390-TN) and the Recombinant Human TRANCE/RANK L/TNFSF11 (Catalog # 6449-TEC)?

    6449-TEC is the truncated version of 390-TN, and it contains a 10-His tag in the N-terminus. The bioactivity of 390-TN and 6449-TEC are measured in the same assay described in the datasheet, "Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells." However, 390-TN utilizes a cross-linking antibody, MAB050, as it requires receptor trimerization which results in higher bioactivity. The ED50 for 390-TN is 1.5-7.5 ng/mL in the presence of MAB050, while the ED50 for 6449-TEC is 2-12 ng/mL.

Product Documents for Recombinant Human TRANCE/RANK L/TNFSF11 Protein

Certificate of Analysis

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