Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli-expressed) Best Seller
Catalog # 6449-TEC | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Source: | E. coli |
Accession #: | AAC51762 |
Applications: | Bioactivity |
Citations for Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli-expressed) (3)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli-expressed) include:
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Species: Human
Sample Types: Whole Cells
Applications: BioassayR Liu et al. (2022-01-06), Bacterial infections exacerbate myeloma bone disease Journal of Translational Medicine, 2022-020(1):16.
PMID: 34991592 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Chen et al. (2021-05-08), Plastrum testudinis extract suppresses osteoclast differentiation via the NF-&kappaB signaling pathway and ameliorates senile osteoporosis Journal of ethnopharmacology, 2021-0276(0):114195.
PMID: 33974944 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-08-25), Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways Mol Med Rep, 2016-014(4):3620-6.
PMID: 27572279
There are no citations that match your criteria.
FAQs for Recombinant Human TRANCE/RANK L/TNFSF11 (E. coli-expressed)
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What are the differences between the Recombinant Human TRANCE/RANK L/TNFSF11 Protein (Catalog # 390-TN) and the Recombinant Human TRANCE/RANK L/TNFSF11 (Catalog # 6449-TEC)?
6449-TEC is the truncated version of 390-TN, and it contains a 10-His tag in the N-terminus. The bioactivity of 390-TN and 6449-TEC are measured in the same assay described in the datasheet, "Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells." However, 390-TN utilizes a cross-linking antibody, MAB050, as it requires receptor trimerization which results in higher bioactivity. The ED50 for 390-TN is 1.5-7.5 ng/mL in the presence of MAB050, while the ED50 for 6449-TEC is 2-12 ng/mL.