Recombinant Human TRAIL/TNFSF10 Protein Best Seller
Catalog # 375-TL | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Source: | NS0 |
Accession #: | P50591 |
Structure / Form: | Noncovalently-linked homotrimer and disulfide-linked homodimer |
Applications: | Bioactivity |
Citations for Recombinant Human TRAIL/TNFSF10 Protein (52)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human TRAIL/TNFSF10 Protein include:
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Species: Human
Sample Types: Whole Cells
Applications: BioassayY Shlyakhtin et al. (2023-02-25), BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity Nature Communications, 2023-014(1):1085.
PMID: 36841849 -
Species: Complex Species Category
Sample Types: Whole Cells
Applications: BioassayBhuyan S et al. (2022-09-29), Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense. Front Immunol, 2022-013(0):933329.
PMID: 36248858 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySM Woo et al. (2022-09-24), Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5 Cell Death Disease, 2022-09-24;13(9):821.
PMID: 36153316 -
Species: Human
Sample Types: Transduced Whole Cells
Applications: BioassayJ Joung et al. (2022-03-25), CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity Nature Communications, 2022-013(1):1606.
PMID: 35338135 -
Species: Human
Sample Types: Whole Cell
Applications: BioassayBT Wang et al. (2021-10-28), Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199 Molecular Cancer Therapeutics, 2021-10(0).
PMID: 34711645 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureM Lee et al. (2020-11-10), Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating�hepatic dipeptidyl peptidase-4 expression Sci Rep, 2020-110(1):19429.
PMID: 33173107 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayK Landgraf et al. (2020-10-20), The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG Cell Rep, 2020-133(3):108295.
PMID: 33086065 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureH Forde et al. (2020-10-01), TRAIL inhibits oxidative stress in human aortic endothelial cells exposed to pro-inflammatory stimuli Physiol Rep, 2020-18(20):e14612.
PMID: 33080110 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureSM Woo et al. (2019-12-06), Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation Biomolecules, 2019-19(12).
PMID: 31817770 -
Species: Human, Xenograft
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In VivoM Hong et al. (2019-11-19), Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation Cells, 2019-18(11).
PMID: 31752383 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySP O'Hara et al. (2019-10-28), The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1 J. Biol. Chem., 2019-10(0).
PMID: 31659122 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureWY Kong et al. (2019-09-19), Zebularine and trichostatin A sensitized human breast adenocarcinoma cells towards tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis Heliyon, 2019-05(9):e02468.
PMID: 31687564 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureEA Kim et al. (2019-07-19), MiR-1208 Increases the Sensitivity to Cisplatin by Targeting TBCK in Renal Cancer Cells Int J Mol Sci, 2019-020(14).
PMID: 31331056 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySM Woo et al. (2019-07-02), Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma Int J Mol Sci, 2019-020(13).
PMID: 31269715 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayEB Jo et al. (2019-05-24), Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells BMC Cancer, 2019-019(1):496.
PMID: 31126284 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Li et al. (2019-02-12), Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL-involved degranulation manner J. Leukoc. Biol., 2019-00(0).
PMID: 30748035 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBR Kim et al. (2019-01-28), RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer Oncogene, 2019-00(0).
PMID: 30692634 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Tian et al. (2018-11-16), Aldehyde Dehydrogenase 1 (ALDH1) Promotes the Toxicity of TRAIL in Non-Small Cell Lung Cancer Cells via Post-Transcriptional Regulation of MEK-1 Expression Cell. Physiol. Biochem., 2018-151(1):217-227.
PMID: 30448845 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayB Lian et al. (2018-09-26), miR-128 Targets the SIRT1/ROS/DR5 Pathway to Sensitize Colorectal Cancer to TRAIL-Induced Apoptosis Cell. Physiol. Biochem., 2018-049(6):2151-2162.
PMID: 30257253 -
Species: Porcine
Sample Types: Whole Cells
Applications: BioassayCJ Williams et al. (2018-03-22), Mutations in osteoprotegerin account for the CCAL1 locus in calcium pyrophosphate deposition disease Osteoarthr. Cartil., 2018-00(0).
PMID: 29578045 -
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance (SPRAW Clarke et al. (2018-03-05), An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease MAbs, 2018-00(0):1-43.
PMID: 29436901 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDY Liang et al. (2018-02-14), ShDcR3 sensitizes TRAIL-resistant HCC cells by inducing caspase-dependent apoptosis while suppressing NF-?B dependent cFLIPL expression PLoS ONE, 2018-013(2):e0191545.
PMID: 29444104 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySH Hong et al. (2018-02-09), Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells Exp. Mol. Med., 2018-050(2):e443.
PMID: 29422545 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayP Zhang et al. (2017-12-12), Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF Mutated human Colorectal Cancer Mol. Cancer Res., 2017-10(0).
PMID: 29233910 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySM Woo et al. (2017-11-20), Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin Oncotarget, 2017-18(63):106672-106684.
PMID: 29290980 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMJ Mitchell et al. (2017-03-20), Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis Nat Commun, 2017-08(0):14179.
PMID: 28317839 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBo Ra You et al. (2017-03-14), Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells. Oncotarget, 2017-00(0):1949-2553.
PMID: 28099148 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Yang et al. (2017-03-01), Chemoresistance is associated with overexpression of HAX-1, inhibition of which resensitizes drug-resistant breast cancer cells to chemotherapy Tumour Biol, 2017-039(3):1010428317692.
PMID: 28347249 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Liang et al. (2017-01-18), Downregulation of DcR3 sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis Onco Targets Ther, 2017-010(0):417-428.
PMID: 28176915 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySH Lee et al. (2016-10-27), Potential Role of CD133 Expression in the Susceptibility of Human Liver Cancer Stem-Like Cells to TRAIL Oncol. Res., 2016-124(6):495-509.
PMID: 28281970 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-04-19), TNFSF10/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis Oncotarget, 2016-07(16):21416-27.
PMID: 26982083 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLizarraga F et al. (2015-08-20), Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells. PLoS ONE, 2015-010(8):e0135929.
PMID: 26291714 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMeng X et al. (2014-07-25), Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression. J Biol Chem, 2014-0289(30):20543-58.
PMID: 24895135 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJang et al. (2014-06-13), TRAIL enhances apoptosis of human hepatocellular carcinoma cells sensitized by hepatitis C virus infection: therapeutic implications. PLoS ONE, 2014-09(6):e98171.
PMID: 24927176 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMathieu J et al. (2014-03-20), Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency. Cell Stem Cell, 2014-014(5):592-605.
PMID: 24656769 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayYou B et al. (2014-03-12), Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels. Int J Oncol, 2014-044(5):1745-55.
PMID: 24626405 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWehrkamp et al. (2014-03-06), XIAP antagonist embelin inhibited proliferation of cholangiocarcinoma cells. PLoS ONE, 2014-09(3):e90238.
PMID: 24603802 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKim et al. (2014-01-16), Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma. Stem Cells Transl Med, 2014-03(2):172-82.
PMID: 24436439 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayYang et al. (2013-12-02), Inhibition of PP2A activity confers a TRAIL-sensitive phenotype during malignant transformation. Mol Cancer Res, 2013-112(2):217-27.
PMID: 24296757 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTatsuta T et al. (2013-11-28), Sialic acid-binding lectin (leczyme) induces apoptosis to malignant mesothelioma and exerts synergistic antitumor effects with TRAIL. Int J Oncol, 2013-144(2):377-84.
PMID: 24297392 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDe Chiara A et al. (2013-07-03), Characterization of cytosolic proliferating cell nuclear antigen (PCNA) in neutrophils: antiapoptotic role of the monomer. J Leukoc Biol, 2013-094(4):723-31.
PMID: 23825390 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAkimoto et al. (2013-02-04), Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation. Stem Cells Dev, 2013-022(9):1370-86.
PMID: 23231075 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson TR et al. (2012-07-26), Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-0487(7408):505-9.
PMID: 22763448 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySagiv et al. (2012-07-02), Granule exocytosis mediates immune surveillance of senescent cells. Oncogene, 2012-032(15):1971-7.
PMID: 22751116 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKang Z et al. (2011-03-08), Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response. Clin Cancer Res, 2011-017(10):3181-92.
PMID: 21385927 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayVanhecke E et al. (2011-02-24), Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival. Clin. Cancer Res., 2011-017(7):1741-52.
PMID: 21350004 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPark SJ et al. (2009-01-24), Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. Biochem. Pharmacol., 2009-077(8):1328-36.
PMID: 19426671 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChamoux E et al. (2008-08-01), Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway. J. Cell. Physiol., 2008-0216(2):536-42.
PMID: 18338379 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayInglefield JR et al. (2008-04-01), TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN. J. Interferon Cytokine Res., 2008-028(4):253-63.
PMID: 18439103 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLocklin RM et al. (2007-12-07), Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis. Mol. Cancer Ther., 2007-16(12):3219-28.
PMID: 18065493 -
Species: Human, Mouse
Sample Types: Whole Cells
Applications: BioassayDumitru CA et al. (2006-04-24), TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis. Oncogene, 2006-025(41):5612-25.
PMID: 16636669 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCross SS et al. (2006-04-15), Osteoprotegerin (OPG)--a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? Int. J. Cancer, 2006-0118(8):1901-8.
PMID: 16287088
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Customer Reviews for Recombinant Human TRAIL/TNFSF10 Protein (1)
Customer Images
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Application: Cell Viability AssayReason for Rating: Results met expectationVerified Customer | Posted 07/21/2016
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FAQs for Recombinant Human TRAIL/TNFSF10 Protein
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This protein datasheet indicates I need to use a cross-linking antibody, Catalog # MAB050, for biological activity. What is this antibody and is it really necessary?
The antibody is directed against a 6x histidine repeat and is recommended for use as a cross-linker of proteins with 6x his-tag. Crosslinking is often used for proteins that require receptor trimerization and can result greater biological activity. R&D Systems Quality Control tests the performance of these proteins in the presence of the cross-linking antibody. Therefore, it is necessary to use this antibody when trying to achieve the same level of specific activity described in the datasheet.