Can Recombinant Human PDGF-BB Protein, CF (Catalog # 220-BB) be reconstituted in a buffer containing BSA?

Name: Recombinant Human PDGF-BB Protein, CF
Brand: R&D Systems
SKU: 220-BB
Rating: 5 (10 reviews)

BSA preparations may contain minor impurities that can impact assay results, and assays involving Recombinant Human PDGF-BB Protein, CF (Catalog # 220-BB) can be influenced by these minor impurities. For this reason, we recommend reconstituting 220-BB to 100 ug/mL in 4 mM HCl. Including BSA in a buffer may be beneficial when diluting proteins to working concentrations less than 10 ug/mL. If BSA is included in an experiment involving 220-BB, we would recommend running a BSA-only control.

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Catalog # 220-BB | R&D Systems, Inc. a Bio-Techne Brand

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Citations (167)

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Key Product Details

Source:	E. coli
Accession #:	P01127.1
Structure / Form:	Disulfide-linked homodimer
Applications:	Bioactivity

View Full Technical Details for Recombinant Human PDGF-BB Protein, CF

Product Specifications for Recombinant Human PDGF-BB Protein, CF

Source	E. coli-derived human PDGF-BB protein Ser82-Thr190
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin level	<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Ser82
Predicted Molecular Mass	12.3 kDa (monomer)
SDS-PAGE	12 kDa, reducing conditions
Activity	Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED₅₀ for this effect is 1.5-6 ng/mL.

Scientific Data Examples for Recombinant Human PDGF-BB Protein, CF

	Recombinant Human PDGF-BB Protein Bioactivity Recombinant Human PDGF-BB (Catalog # 220-BB) stimulates cell proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner. The ED₅₀ for this effect is 1.5-6 ng/mL.
	Recombinant Human PDGF-BB Protein SDS-PAGE 1 μg/lane of Recombinant Human PDGF-BB was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 13 kDa and 28 kDa, respectively.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

220-BB

Formulation	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution	Reconstitute at 100 μg/mL in sterile 4 mM HCl. Reconstitution Buffer Available: Size / Price Qty Loading... RB03:
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: PDGF-BB

Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the alpha ‑granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGF-AA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed alpha and beta. Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL-2 secretion accompanied by a down-regulation of IL-4 and IFN-gamma production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.

Item	Value
Long Name	Platelet-derived Growth Factor BB
Entrez Gene IDs	5155 (Human); 24628 (Rat)
Alternate Names	PDGF-BB, PDGFBB, c-sis;IBGC5;PDGF2;PDGF-2;PDGFB;Platelet-derived growth factor subunit B;SIS;SSV

Citations for Recombinant Human PDGF-BB Protein, CF (167)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human PDGF-BB Protein, CF include:

Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HM Yang et al. (2023-02-18), Identification of cell-biologic mechanisms of coronary artery spasm and its ex vivo diagnosis using peripheral blood-derived iPSCs Biomaterials research, 2023-027(1):16.
PMID: 36803875
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Wenhua et al. (2023-01-23), Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma Cancer Medicine, 2023-00(0).
PMID: 36691359
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Cai et al. (2022-12-14), The extract from Hyssopus cuspidatus Boriss. Prevents bronchial airway remodeling by inhibiting mouse bronchial wall thickening and hASMC proliferation and migration Journal of ethnopharmacology, 2022-10(0):116047.
PMID: 36528211
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AA Widjaja et al. (2022-12-05), Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease Nature Communications, 2022-113(1):7497.
PMID: 36470928
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Gc et al. (2022-11-08), alpha2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth JCI Insight, 2022-17(21).
PMID: 36345944
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Dos Santos et al. (2022-11-02), Generation of Functional Immortalized Human Corneal Stromal Stem Cells International Journal of Molecular Sciences, 2022-123(21).
PMID: 36362184
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

W He et al. (2022-10-18), Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion Cell bioscience, 2022-10-18;12(1):175.
PMID: 36258228
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Filliol et al. (2022-10-05), Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis Nature, 2022-10(0).
PMID: 36198802
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Tobiume et al. (2022-09-30), Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer Oncology Letters, 2022-024(5):417.
PMID: 36245829
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Chandrasek et al. (2022-09-15), UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide and promoted by PDGF in fibroblast-like synoviocytes: Evidence of a redox control mechanism PLoS ONE, 2022-017(9):e0274420.
PMID: 36107941
Species: Mouse
Sample Types: Whole Cells
Applications: Migration Bioassay

A Radwanska et al. (2022-08-22), Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis JCI Insight, 2022-07(16).
PMID: 35993367
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G Ishikawa et al. (2022-07-31), Peficitinib inhibits fibroblast-like synoviocyte activation and angiogenic vascular endothelial tube formation via inhibitory effects on PDGF and VEGF signaling in addition to JAK Journal of pharmacological sciences, 2022-0150(2):74-80.
PMID: 36055754
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Das et al. (2022-07-11), Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1alpha-dependent expression of collagen I (alpha2) during renal fibrosis The Journal of Biological Chemistry, 2022-00(0):102246.
PMID: 35835217
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MC Beer et al. (2022-06-18), Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor Biomolecules, 2022-012(6).
PMID: 35740973
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

I Nanda et al. (2022-05-29), Genetic Characterization of Rat Hepatic Stellate Cell Line HSC-T6 for In Vitro Cell Line Authentication Cells, 2022-011(11).
PMID: 35681478
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

R Boi et al. (2022-05-05), Modified lipid metabolism and cytosolic phospholipase A2 activation in mesangial cells under pro-inflammatory conditions Scientific Reports, 2022-012(1):7322.
PMID: 35513427
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Zhou et al. (2022-05-03), SM22alpha-lineage niche cells regulate intramembranous bone regeneration via PDGFRbeta-triggered hydrogen sulfide production Cell Reports, 2022-039(5):110750.
PMID: 35508129
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

Salokas K et al. (2022-04-05), Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-023(6):e54041.
PMID: 35384245
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kim E et al. (2022-03-28), Overexpression of CEACAM6 activates Src-FAK signaling and inhibits anoikis, through homophilic interactions in lung adenocarcinomas. Transl Oncol, 2022-020(0):101402.
PMID: 35358791
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Joannes et al. (2022-03-09), Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis Toxicology and Applied Pharmacology, 2022-0441(0):115972.
PMID: 35276128
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Li et al. (2022-01-28), MiR-34a-3p suppresses pulmonary vascular proliferation in acute pulmonary embolism rat by targeting DUSP1 Bioscience Reports, 2022-00(0).
PMID: 34778900
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SF Mause et al. (2022-01-14), Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis International Journal of Molecular Sciences, 2022-023(2).
PMID: 35055054
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Culenova et al. (2021-11-19), Isolation, Culture and Comprehensive Characterization of Biological Properties of Human Urine-Derived Stem Cells International Journal of Molecular Sciences, 2021-122(22).
PMID: 34830384
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Looprasert et al. (2021-05-17), Gold Nanoparticles Affect Pericyte Biology and Capillary Tube Formation Pharmaceutics, 2021-013(5).
PMID: 34067883
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YJ Liao et al. (2021-03-13), Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl4 and TAA-Induced Liver Fibrosis in Mice International Journal of Molecular Sciences, 2021-022(6).
PMID: 33805788
Species: Rabbit
Sample Types: In Vivo
Applications: Bioassay

S Yang et al. (2021-03-04), Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy Cell Death and Differentiation, 2021-00(0).
PMID: 33664479
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Standard

R Beckmann et al. (2021-01-29), DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously Nature Communications, 2021-012(1):708.
PMID: 33514724
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

T Otsuka et al. (2021-01-07), Control of mesenchymal cell fate via application of FGF-8b in vitro Stem Cell Research, 2021-051(0):102155.
PMID: 33445073
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Fang et al. (2020-12-14), Zinc salicylate reduces airway smooth muscle cells remodelling by blocking mTOR and activating p21(Waf1/Cip1) The Journal of nutritional biochemistry, 2020-10(0):108563.
PMID: 33326841
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Y Yamamoto et al. (2020-12-01), Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model Scientific Reports, 2020-110(1):20936.
PMID: 33262357
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

L Song et al. (2020-11-17), Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy Nat Commun, 2020-111(1):5842.
PMID: 33203880
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Song et al. (2020-11-05), PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease JCI Insight, 2020-10(0).
PMID: 33001865
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YY Liang et al. (2020-10-14), RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner Cell Death Dis, 2020-111(10):855.
PMID: 33057010
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SK Meurer et al. (2020-08-03), Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells Cell. Signal., 2020-074(0):109731.
PMID: 32758668
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Maity et al. (2020-07-30), TGFb acts through PDGFRb to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression J. Biol. Chem., 2020-00(0).
PMID: 32732288
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Z Al-Bakri et al. (2020-07-18), Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood Regenerative Therapy, 2020-015(0):53-63.
PMID: 33426202
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

X Li et al. (2020-07-09), Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice J. Cell. Mol. Med., 2020-00(0).
PMID: 32643868
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Oka et al. (2020-05-20), Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis Sci Rep, 2020-010(1):8330.
PMID: 32433495
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Wei et al. (2020-04-22), Notch signalling drives synovial fibroblast identity and arthritis pathology Nature, 2020-0582(7811):259-264.
PMID: 32499639
Species: N/A
Sample Types: Complex Sample Type
Applications: Bioassay

M Aliabouzar et al. (2020-03-26), Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds Ultrason Sonochem, 2020-066(0):105109.
PMID: 32248042
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

W Chen et al. (2020-03-10), Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells J. Cell. Mol. Med., 2020-00(0).
PMID: 32155686
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

J Heo et al. (2020-03-06), Vascular Smooth Muscle Cell-Derived Exosomal MicroRNAs Regulate Endothelial Cell Migration Under PDGF Stimulation Cells, 2020-09(3).
PMID: 32155804
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

B Wang et al. (2020-02-19), PERK Inhibition Mitigates Restenosis andï¿½Thrombosis: A Potential Low-Thrombogenic Antirestenotic Paradigm JACC Basic Transl Sci, 2020-05(3):245-263.
PMID: 32215348
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

NA Agabalyan et al. (2019-11-14), Adult Human Dermal Progenitor Cell Transplantation Modulates the Functional Outcome of Split-Thickness Skin Xenografts Stem Cell Reports, 2019-113(6):1068-1082.
PMID: 31735655
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Wang et al. (2019-10-15), miR-29a Regulates the Proliferation and Migration of Human Arterial Smooth Muscle Cells in Arteriosclerosis Obliterans of the Lower Extremities Kidney Blood Press. Res., 2019-144(5):1219-1232.
PMID: 31614351
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TN Vu et al. (2019-09-11), Interferon-Î³ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation Respir. Res., 2019-020(1):206.
PMID: 31511015
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Messerschm et al. (2019-06-30), Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-025(0):329-344.
PMID: 31341381
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P Luan et al. (2019-06-28), NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARgamma Nat Commun, 2019-010(1):2882.
PMID: 31253783
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Muraguchi et al. (2019-05-11), IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance J. Dermatol. Sci., 2019-00(0).
PMID: 31122679
Species: N/A
Sample Types: DNA
Applications: Bioassay

H Gan et al. (2019-05-08), Proximity hybridization-induced on particle DNA walker for ultrasensitive protein detection Anal. Chim. Acta, 2019-01074(0):142-149.
PMID: 31159934
Sample Types: Hydrogel
Applications: Bioassay

T Emi et al. (2019-03-16), Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels Molecules, 2019-024(6).
PMID: 30884862
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Colunga et al. (2019-03-05), Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair Cell Rep, 2019-026(10):2566-2579.e10.
PMID: 30840882
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MFM Gerli et al. (2019-02-07), Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells Stem Cell Reports, 2019-00(0).
PMID: 30745033
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Higashi et al. (2019-02-01), Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK suppression Cell. Signal., 2019-057(0):20-Oct.
PMID: 30716386
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SI Motegi et al. (2019-01-16), Possible contribution of PDGF-BB-induced autophagy in dermatofibrosarcoma protuberans: Autophagy marker Atg5 could be a differential marker between dermatofibrosarcoma protuberans and dermatofibroma J. Dermatol. Sci., 2019-00(0).
PMID: 30704939
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Kano et al. (2019-01-15), Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation Nat Commun, 2019-010(1):224.
PMID: 30644389
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Li et al. (2019-01-01), MicroRNA-320 targeting neuropilin 1 inhibits proliferation and migration of vascular smooth muscle cells and neointimal formation Int J Med Sci, 2019-016(1):106-114.
PMID: 30662334
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Zhang et al. (2018-12-31), HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity JACC Basic Transl Sci, 2018-13(6):782-795.
PMID: 30623138
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Delsing et al. (2018-11-05), Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier Stem Cells, 2018-10(0).
PMID: 30171748
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Lambers et al. (2018-11-01), Mechanism of anti-remodelling action of treprostinil in human pulmonary arterial smooth muscle cells PLoS ONE, 2018-113(11):e0205195.
PMID: 30383775
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ACY Chang et al. (2018-08-27), Telomere shortening is a hallmark of genetic cardiomyopathies Proc. Natl. Acad. Sci. U.S.A., 2018-00(0).
PMID: 30150400
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Dubrac et al. (2018-08-27), NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy Nat Commun, 2018-09(1):3463.
PMID: 30150707
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Sambathkum et al. (2018-05-11), Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells PLoS ONE, 2018-013(5):e0197046.
PMID: 29750821
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LR Penke et al. (2018-05-07), FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis J. Clin. Invest., 2018-00(0).
PMID: 29733296
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Y Zhang et al. (2018-04-23), Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy Cell. Physiol. Biochem., 2018-046(4):1704-1715.
PMID: 29698960
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

B Bergström et al. (2018-03-20), Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1? on rheumatoid arthritis fibroblast-like synoviocytes Arthritis Res. Ther., 2018-020(1):49.
PMID: 29554943
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JM Dave et al. (2018-02-15), Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain Dev. Cell, 2018-00(0).
PMID: 29456135
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

VC Pai et al. (2018-02-13), The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells J. Biomed. Sci., 2018-025(1):14.
PMID: 29439742
Species: Human
Sample Types: Whole Cells

L Peix et al. (2018-01-30), Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis Sci Rep, 2018-08(1):1906.
PMID: 29382921
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KB Sugg et al. (2017-12-13), Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling Am. J. Physiol., Cell Physiol., 2017-10(0).
PMID: 29341790
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

SB Mamer et al. (2017-11-27), Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics Sci Rep, 2017-17(1):16439.
PMID: 29180757
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Kitano et al. (2017-08-23), Combination therapy using molecular-targeted drugs modulates tumor microenvironment and impairs tumor growth in renal cell carcinoma Cancer Med, 2017-00(0).
PMID: 28834289
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TM Wang et al. (2017-07-12), microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype J. Cell. Mol. Med., 2017-00(0).
PMID: 28699690
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Dagnell et al. (2017-07-06), Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure J. Biol. Chem., 2017-00(0).
PMID: 28684416
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P Piñol-Jura et al. (2017-06-12), Platelet-Derived Growth Factor BB Influences Muscle Regeneration in Duchenne Muscle Dystrophy Am. J. Pathol., 2017-00(0).
PMID: 28618254
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TH Su et al. (2017-05-11), Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis Sci Rep, 2017-07(1):1728.
PMID: 28496142
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Núñez-Told et al. (2017-04-21), Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation BMC Cell Biol., 2017-018(1):21.
PMID: 28427322
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Wu et al. (2017-04-12), Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-? as a key for entry PLoS Pathog., 2017-013(4):e1006281.
PMID: 28403202
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

S Pan et al. (2017-03-15), Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling Am J Transl Res, 2017-09(3):1307-1316.
PMID: 28386356
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Liu et al. (2017-03-09), Urethral reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model Stem Cell Res Ther, 2017-08(1):63.
PMID: 28279224
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Haipeng Guo (2017-03-01), Isoquercitrin protects against pulmonary hypertension via inhibiting PASMCs proliferation Clin. Exp. Pharmacol. Physiol., 2017-00(0).
PMID: 27873355
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Pap et al. (2017-02-28), Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling Kidney Blood Press. Res, 2017-042(1):16-32.
PMID: 28253513
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DH Heiland et al. (2017-01-24), c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas Oncotarget, 2017-00(0).
PMID: 28036297
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Huimin Mao (2016-12-21), Zedoarondiol Inhibits Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells Proliferation via Regulating AMP-Activated Protein Kinase Signaling Pathway Cell. Physiol. Biochem, 2016-140(6):1506-1520.
PMID: 27997894
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Xiaoming Wei (2016-12-07), Biological characteristics of embryonic epicardial cells in vitro correlate with embryonic day Acta Biochim. Biophys. Sin. (Shanghai), 2016-10(0).
PMID: 27932393
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Robert M Lavker (2016-10-07), miR-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways FASEB J., 2016-10(0).
PMID: 27825105
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-09-21), Interferon-? blocks signalling through PDGFR? in human brain pericytes J Neuroinflammation, 2016-013(1):249.
PMID: 27654972
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016-09-07), Pericyte-fibroblast transition promotes tumor growth and metastasis Proc Natl Acad Sci USA, 2016-0113(38):E5618-E5627.
PMID: 27608497
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

(2016-09-06), Mesenchymal Stem Cells Reshape and Provoke Proliferation of Articular Chondrocytes by Paracrine Secretion Sci Rep, 2016-06(0):32705.
PMID: 27596239
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

(2016-08-16), Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow-derived counterparts J Tissue Eng, 2016-07(0):2041731416661.
PMID: 27579159
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-07-08), Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci Nat Commun, 2016-07(0):12092.
PMID: 27386823
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-07-05), Platelet-Derived Growth Factor in the Ovarian Follicle Attracts the Stromal Cells of the Fallopian Tube Fimbriae PLoS ONE, 2016-011(7):e0158266.
PMID: 27379403
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bogershausen N et al. (2015-08-17), RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. J Clin Invest, 2015-0125(9):3585-99.
PMID: 26280580
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Amarachintha S et al. (2015-07-24), Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation Through Toll-Like Receptor Signaling. Stem Cells, 2015-033(11):3382-96.
PMID: 26212365
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wilson J et al. (2015-04-23), Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells from Subjects with Pulmonary Arterial Hypertension Is Activated through JNK and p38 MAPK. 2015-00(0).
PMID: 25905460
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jia D et al. (2015-03-30), Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE, 2015-010(3):e0121939.
PMID: 25822822
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Huang et al. (2015-03-27), Thrombomodulin promotes corneal epithelial wound healing. PLoS ONE, 2015-010(3):e0122491.
PMID: 25816372
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jayaprakash P et al. (2015-03-03), Hsp90alpha and Hsp90beta together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci, 2015-0128(8):1475-80.
PMID: 25736295
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhang F et al. (2015-01-26), The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration. J Biol Chem, 2015-0290(13):8232-42.
PMID: 25623072
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hostettler K et al. (2014-12-12), Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis. Respir Res, 2014-115(1):157.
PMID: 25496490
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kureshi A et al. (2014-10-21), Human corneal stromal stem cells exhibit survival capacity following isolation from stored organ-culture corneas. Invest Ophthalmol Vis Sci, 2014-155(11):7583-8.
PMID: 25335980
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Niu F et al. (2014-08-27), Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders. J Neurosci, 2014-034(35):11812-25.
PMID: 25164676
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Su C et al. (2014-08-08), Lutein inhibits the migration of retinal pigment epithelial cells via cytosolic and mitochondrial Akt pathways (lutein inhibits RPE cells migration). Int J Mol Sci, 2014-015(8):13755-67.
PMID: 25110866
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yang et al. (2014-08-01), Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells. Cell Commun Signal, 2014-012(1):44.
PMID: 25080971
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oleinik N et al. (2014-08-01), Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation. J Biol Chem, 2014-0289(38):26383-94.
PMID: 25086046
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhao C et al. (2014-06-11), Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunol, 2014-0193(2):879-88.
PMID: 24920846
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Tsai T et al. (2014-04-24), Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor. PLoS ONE, 2014-09(4):e95443.
PMID: 24763086
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kondo et al. (2014-04-08), Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. PLoS ONE, 2014-09(4):e94114.
PMID: 24714781
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Miller C et al. (2014-03-27), Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genet, 2014-010(3):e1004263.
PMID: 24676100
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hayes B et al. (2014-03-25), Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis. PLoS ONE, 2014-09(3):e92925.
PMID: 24667490
Species: Human, Rat
Sample Types: Whole Cells
Applications: Bioassay

Gobin B et al. (2014-03-05), Imatinib mesylate exerts anti-proliferative effects on osteosarcoma cells and inhibits the tumour growth in immunocompetent murine models. PLoS ONE, 2014-09(3):e90795.
PMID: 24599309
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wollin L et al. (2014-02-20), Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis. J Pharmacol Exp Ther, 2014-0349(2):209-20.
PMID: 24556663
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lo H et al. (2014-02-03), TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin, 2014-035(3):339-50.
PMID: 24487964
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhang et al. (2014-01-17), Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma. Cell Death Differ, 2014-021(5):720-34.
PMID: 24440911
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Camorani S et al. (2014-01-02), Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRbeta aptamer. Mol Ther, 2014-022(4):828-41.
PMID: 24566984
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bastiaans J et al. (2013-12-19), Thrombin induces epithelial-mesenchymal transition and collagen production by retinal pigment epithelial cells via autocrine PDGF-receptor signaling. Invest Ophthalmol Vis Sci, 2013-154(13):8306-14.
PMID: 24302586
Species: Primate - Chlorocebus aethiops (African Green Monkey)
Sample Types: Whole Cells
Applications: Bioassay

Gottlieb-Abraham et al. (2013-10-16), Src-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites. Mol Biol Cell, 2013-124(24):3881-95.
PMID: 24131997
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gadepalli R et al. (2013-09-11), Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. J Biol Chem, 2013-0288(43):30815-31.
PMID: 24025335
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Karki R et al. (2013-07-29), Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation. Exp Cell Res, 2013-0319(20):3238-50.
PMID: 23906924
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hollborn M et al. (2013-03-26), Cytotoxic effects of curcumin in human retinal pigment epithelial cells. PLoS ONE, 2013-08(3):e59603.
PMID: 23555722
Species: Human
Sample Types: Serum
Applications: Bioassay

Li et al. (2013-03-14), Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency. Arterioscler Thromb Vasc Biol, 2013-033(5):1028-35.
PMID: 23493289
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Song S et al. (2013-02-28), Distinct transcriptional profiles of angioblasts derived from human embryonic stem cells. Exp Cell Res, 2013-0319(8):1136-45.
PMID: 23458169
Species: Human, Rat
Sample Types: Whole Cells
Applications: Bioassay

Silvestre-Roig C et al. (2013-02-21), Inactivation of nuclear factor-Y inhibits vascular smooth muscle cell proliferation and neointima formation. Arterioscler Thromb Vasc Biol, 2013-033(5):1036-45.
PMID: 23430616
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cheng J et al. (2013-02-18), ROS-mediated downregulation of MYPT1 in smooth muscle cells: a potential mechanism for the aberrant contractility in atherosclerosis. Lab Invest, 2013-093(4):422-33.
PMID: 23419712
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Di Maggio N et al. (2012-07-01), Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c. Stem Cells, 2012-030(7):1455-64.
PMID: 22495904
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Davis-Dusenbery BN et al. (2011-06-13), Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4. J. Biol. Chem., 2011-0286(32):28097-110.
PMID: 21673106
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Roobrouck VD et al. (2011-05-01), Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions. Stem Cells, 2011-029(5):871-82.
PMID: 21433224
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chang Y et al. (2011-02-22), TH17 cytokines induce human airway smooth muscle cell migration. J. Allergy Clin. Immunol., 2011-0127(4):1046-53.e1-2.
PMID: 21345484
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Evans IM et al. (2011-01-18), Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol., 2011-031(6):1174-85.
PMID: 21245381
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Roelandt P et al. (2010-08-11), Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010-05(8):e12101.
PMID: 20711405
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lorquet S et al. (2010-05-19), Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment. FASEB J., 2010-024(10):3782-95.
PMID: 20484670
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Shan L et al. (2010-05-14), Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. J. Immunol., 2010-0184(12):7134-43.
PMID: 20483734
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ball SG et al. (2010-03-15), Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells. Biochem. J., 2010-0427(1):29-40.
PMID: 20102335
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nilsson MB et al. (2010-03-08), Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors. Oncogene, 2010-029(20):2938-49.
PMID: 20208561
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Liu R et al. (2009-11-24), KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood, 2009-1115(4):887-95.
PMID: 19965636
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Kobayashi T et al. (2009-02-25), Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells. Kidney Int., 2009-075(11):1173-83.
PMID: 19242504
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

van Steensel L et al. (2009-02-21), Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy. Invest. Ophthalmol. Vis. Sci., 2009-050(7):3091-8.
PMID: 19234339
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rice JW et al. (2008-12-01), Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis. Arthritis Rheum., 2008-158(12):3765-75.
PMID: 19035474
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jiang M et al. (2008-08-01), Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice. J. Clin. Invest., 2008-0118(8):2733-46.
PMID: 18618022
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hilberg F et al. (2008-06-15), BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res., 2008-068(12):4774-82.
PMID: 18559524
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wagsater D et al. (2008-05-22), Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression. Atherosclerosis, 2008-0202(2):415-23.
PMID: 18573494
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

He S et al. (2008-04-30), Connective tissue growth factor as a mediator of intraocular fibrosis. Invest. Ophthalmol. Vis. Sci., 2008-049(9):4078-88.
PMID: 18450591
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nedeau AE et al. (2008-04-25), A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells. Exp. Cell Res., 2008-0314(11):2176-86.
PMID: 18570917
Species: Avian
Sample Types: Whole Tissue
Applications: Bioassay

Tomanek RJ et al. (2008-04-17), Temporally expressed PDGF and FGF-2 regulate embryonic coronary artery formation and growth. Arterioscler. Thromb. Vasc. Biol., 2008-028(7):1237-43.
PMID: 18420995
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gang EJ et al. (2008-03-05), Pax3 activation promotes the differentiation of mesenchymal stem cells toward the myogenic lineage. Exp. Cell Res., 2008-0314(8):1721-33.
PMID: 18395202
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Li R et al. (2007-12-01), PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines. Invest. Ophthalmol. Vis. Sci., 2007-148(12):5722-32.
PMID: 18055825
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

Schweizer PA et al. (2007-06-01), Atrial-radiofrequency catheter ablation mediated targeting of mesenchymal stromal cells. Stem Cells, 2007-025(6):1546-51.
PMID: 17548531
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ball SG et al. (2007-04-30), Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol., 2007-0177(3):489-500.
PMID: 17470632
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tacke F et al. (2007-04-06), Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig. Dis. Sci., 2007-052(12):3404-15.
PMID: 17415633
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dentelli P et al. (2007-02-08), C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood, 2007-0109(10):4264-71.
PMID: 17289809
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hunter I et al. (2006-09-18), Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF-kappaB and MAPK pathways. J. Biol. Chem., 2006-0281(45):34705-15.
PMID: 16982613
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Zeng L et al. (2006-08-24), Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-024(11):2355-66.
PMID: 16931778
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Jiang M et al. (2006-08-10), Pitavastatin attenuates the PDGF-induced LR11/uPA receptor-mediated migration of smooth muscle cells. Biochem. Biophys. Res. Commun., 2006-0348(4):1367-77.
PMID: 16919601
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Riggi N et al. (2006-07-15), Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res., 2006-066(14):7016-23.
PMID: 16849546
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Faraone D et al. (2005-12-01), Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells. Blood, 2005-1107(5):1896-902.
PMID: 16322476
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nagineni CN et al. (2005-04-01), Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-0203(1):35-43.
PMID: 15368539
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Wong AP et al. (2005-02-15), In vitro differences between venous and arterial-derived smooth muscle cells: potential modulatory role of decorin. Cardiovasc. Res., 2005-065(3):702-10.
PMID: 15664397
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tardif G et al. (2004-08-01), Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum., 2004-050(8):2521-30.
PMID: 15334466
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wen FQ et al. (2004-01-12), Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads. Am. J. Respir. Cell Mol. Biol., 2004-030(6):816-22.
PMID: 14722222
Sample Types: N/A
Applications: ELISA (Standard)

Lacoste E et al. (2003-10-01), Platelet concentrates: effects of calcium and thrombin on endothelial cell proliferation and growth factor release. J. Periodontol., 2003-174(10):1498-507.
PMID: 14653397
Species: Rabbit
Sample Types: Whole Cells
Applications: Binding Assay, Bioassay

Nili N et al. (2003-09-01), Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty. Am. J. Pathol., 2003-0163(3):869-78.
PMID: 12937128
Species: Mouse, Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Bioassay

Kovalenko D et al. (2003-02-24), Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J. Biol. Chem., 2003-0278(16):14087-91.
PMID: 12604616
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huaux F et al. (2003-02-15), Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it, 2003-0170(4):2083-92.
PMID: 12574379
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Huaux F et al. (2002-09-01), A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms, 2002-0169(5):2653-61.
PMID: 12193738
Species: Canine, Porcine
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

Desfaits AC et al. (2000-02-01), Growth factors stimulate neointimal cells in vitro and increase the thickness of the neointima formed at the neck of porcine aneurysms treated by embolization. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions, 2000-031(0):498-507.
PMID: 10657429
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

Harwood FL et al. (1999-09-01), Regulation of alpha(v)beta3 and alpha5beta1 integrin receptors by basic fibroblast growth factor and platelet-derived growth factor-BB in intrasynovial flexor tendon cells. 1999-07(5):381-8.
PMID: 10564567
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Akagi Y et al. (1998-09-01), Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res., 1998-058(17):4008-14.
PMID: 9731515

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Recombinant Human PDGF-BB Protein, CF

Name: Anonymous

Application: Immunoassay Standard

Verified Customer | Posted 06/09/2021
Recombinant Human PDGF-BB Protein, CF

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Application: In vitro bioactivity in cell culture

Verified Customer | Posted 10/19/2019
Recombinant Human PDGF-BB Protein, CF

Name: Justin Provencher

Application: CellProlif

Reason for Rating: This was a great control for my cell assay. What a reliable product.

Verified Customer | Posted 10/09/2019
Recombinant Human PDGF-BB Protein, CF

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Recombinant Human PDGF-BB Protein, CF

Name: Tauseef Ahmad

Application: Proof concept for delivery as therapeutic in a controlled delivery system

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Recombinant Human PDGF-BB Protein, CF

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FAQs for Recombinant Human PDGF-BB Protein, CF

Can Recombinant Human PDGF-BB Protein, CF (Catalog # 220-BB) be reconstituted in a buffer containing BSA?

BSA preparations may contain minor impurities that can impact assay results, and assays involving Recombinant Human PDGF-BB Protein, CF (Catalog # 220-BB) can be influenced by these minor impurities. For this reason, we recommend reconstituting 220-BB to 100 ug/mL in 4 mM HCl. Including BSA in a buffer may be beneficial when diluting proteins to working concentrations less than 10 ug/mL. If BSA is included in an experiment involving 220-BB, we would recommend running a BSA-only control.

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Catalog # 220-BB | R&D Systems, Inc. a Bio-Techne Brand

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Citations for Recombinant Human PDGF-BB Protein, CF (167)

Customer Reviews for Recombinant Human PDGF-BB Protein, CF (10)

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Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

Recombinant Human PDGF-BB Protein, CF

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